This article describes various experimental models of seizure and epilepsy. Epilepsy is characterised by recurrent unprovoked seizures. Antiepileptic drug discovery in animal models starts with the assumption that the experimental seizure model mimics human seizure. Hence a drug which suppresses ictogenesis or inhibits epileptogenesis in animal model is a potential antiepileptic drug for human ...

OBJECTIVE Febrile seizure is the most common type of seizure in children. Their incidence is 2-5%. There are different hypotheses about relationship between neurotransmitters and trace elements (such as zinc) and febrile seizure. Zinc, as a major element of some enzymes, plays an important role in the central nervous system (CNS) and can affect some inhibitory mechanisms of CNS. The aim of the ...

This paper will attempt to identify some of the major methodological hurdles that are present when treating or researching seizure conditions using neurobehavioural approaches. An overview of the unique methodological problems that arise with behavioural/psychological treatments will be discussed. The author will focus on personal experiences with complex and simple partial seizures, looking in...

Four patients had prolonged, sensory, simple partial seizures (SPS), lasting up to several days, without associated behavioural impairment. In three patients, the SPS often occurred as a prolonged "aura" before a more overt seizure. Descriptions included: "butterflies", rising epigastric sensation; "a thought in the stomach", and an olfactory sensation. Seizure localisation was frontal in one c...

introduction: seizure is the most common pediatric neurology problem that occurs in 10% of children. the purpose of this study was to determine the recurrence rate of seizures after one year and its relationship with paraclinical findings of the first attack. methods : in a historical cohort analytic study , 131 children with first seizure admitted to shaheed sadoughi hospital between march 200...

BACKGROUND Although routine lumbar puncture (LP) is often recommended as part of the assessment of fever-associated seizures in children, accumulating evidence questions its value and reveals a decrease in its frequency. Our primary hypothesis was that children who present with a single seizure but with no clinical signs of meningism or coma do not require LP as part of initial diagnostic asses...

PURPOSE To study the relationship between seizure-related factors, non-verbal intelligence, and socio-economic status (SES) in a population-based sample of children with epilepsy. METHODS The latest ILAE International classifications of epileptic seizures and syndromes were used to classify seizure types and epileptic syndromes in all 6-12 year old children (N=198) with epilepsy in Hordaland ...

The invertible, compact and Fredholm multiplication operators on generalized Lorentz-Zygmund (GLZ) spaces Lp,q;α, 1 < p ≤ ∞, 1 ≤ q ≤ ∞, α in the Euclidean space R, are characterized in this paper.