SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are closely related DNA-binding proteins that critically enhance its function. We use here genome-wide approaches to gain novel insights into the full spectrum of the target genes and modes of action of this chondrogenic trio. Using the RCS cell line as a faithful model for proliferating/early prehypertrophic gro...

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

Enron ile patlak veren ve Sarbanes Oxley Kanunu (SOX) şekillenen sürecin ardından başta ABD olmak üzere pek çok ülkede kamu gözetim sistemleri kurulmuştur. Bu çalışmada, Uluslararası Bağımsız Denetim Düzenleyicileri Forumu (IFIAR)’na üye olan 9 ülkenin inceleme raporları ihlal edilen BDS’ler açısından incelenmiştir. Denetimin Belgelendirilmesi (BDS 230), Finansal Tabloların Denetiminde Denetçin...

Gastric carcinoma is a heterogeneous malignant disease involving genetic factors. To identify predictive markers for gastric cancer treatment in Chinese patients, we evaluated the association between polymorphisms of the gene encoding cytochrome P450 2A6 (CYP2A6) and outcomes of S-1 plus oxaliplatin (SOX) chemotherapy treatment. Clinical data on 60 consecutive gastric cancer patients receiving ...

A central question in genomic imprinting is how parental-specific DNA methylation of imprinting control regions (ICR) is established during gametogenesis and maintained after fertilization. At the imprinted Igf2/H19 locus, CTCF binding maintains the unmethylated state of the maternal ICR after the blastocyst stage. In addition, evidence from Beckwith-Wiedemann patients and cultured mouse cells ...

pistachio oil has important nutritional and therapeutic properties because of high concentration of essential fatty acids. the extraction method used to obtain natural compounds from raw matter is critical for product quality and especially protection of nutrition value of them. the study was conducted to compare fatty acid composition of pistachio oil extracted by two conventional procedures: ...

The present study investigated the clinical efficacy of S-1 plus oxaliplatin (SOX) regimen, with or without surgery in α-fetoprotein-producing gastric cancer (APGC) with liver metastasis. A total of 24 patients with APGC treated at the Liaocheng People's Hospital between January 2011 and December 2013 were retrospectively reviewed. Clinical efficacy and patient safety were compared between the ...

Thiosulfate-oxidizing sox gene homologues were found at four loci (I, II, III, and IV) on the genome of Bradyrhizobium japonicum USDA110, a symbiotic nitrogen-fixing bacterium in soil. In fact, B. japonicum USDA110 can oxidize thiosulfate and grow under a chemolithotrophic condition. The deletion mutation of the soxY(1) gene at the sox locus I, homologous to the sulfur-oxidizing (Sox) system in...

Aim: In this study, we investigated the immune activity of Sox-9 and Cited-1 in women with placenta accreta. Material Methods: 20 healthy accreta were processed for routine histological tissue processing. Placentals samples dissected fixed 10% formaldehyde solution. Samples embedded paraffin blocks. Clinical biochemical parameters recorded. Placental sections cut from blocks stained immunostain...

The mammalian testis-determining gene Sry and the related Sox genes define a family of transcriptional regulators widely expressed during embryogenesis. Tightly controlled temporal profiles of expression are a feature of the Sox gene family and may be required for initiation of a cascade of gene expression, yet the molecular mechanisms that control Sox gene expression are unknown. We now show t...