Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

Background: The critical role of interleukin-7 (IL-7) in homeostatic proliferation and T cell survival has made it a promising cytokine for the treatment of various clinical conditions, especially those associated with lymphopenia. Methods: In the present study we expressed recombinant human interleukin-7 (rhIL-7) in Chinese hamster ovary (CHO)-K1 cells. CHO-K1 cells were stably transfected ...

the final treatment for diabetes is transplantation of islets of langerhans. one of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol. in this study, the surface of islets of langerhans was coated by cyanuric chloride activated methoxy polyethylene glycol. the effect of polymer coating, at two different reaction times...

a detailed study of ostracoda changes against the stable isotopes of carbon and oxygen acrossthe cenomanian-turonian boundary mass extinction has been fully documented in one section, the south ofengland. this section comprises the uppermost cenomanian to lowermost turonian strata. the comparisonbetween the results obtained in this research and two rival models for the cenomanian-turonian bound...

Asymmetric truxene-based hole-transport material shows stable amorphous film and good efficiency in perovskite solar cell.

Problems of allocating joint costs in a reasonable way arise in many practical situations where people decide to work together to save costs. Cost allocation methods based on game theoretical concepts take into account the strategic aspects of cost allocation situations. We give a survey of cost allocation methods based on the nucleolus and the Shapley value, and introduce also a new one, the s...

Formwork subcontractors that hire open shop workers, rather than union workers can win more contracts and earn more profits from general contractors because of greater agility and lower costs. A subcontractor may earn even more profit if it collaborates with others in a coalition. Payoff functions for individual subcontractors and a group of subcontractors in a coalition are formulated. Profit ...

Environmental conditions encountered by migratory seabirds in their wintering areas can shape their fitness. However, the underlying physiological mechanisms remain largely unknown as birds are relatively inaccessible during winter. To assess physiological condition during this period, we measured corticosterone concentrations in winter-grown primary feathers of female great skuas (Stercorarius...