Among the different computational approaches modelling the dynamics of isogenic cell populations, discrete stochastic models can describe with sufficient accuracy the evolution of small size populations. However, for a systematic and efficient study of their long-time behaviour over a wide range of parameter values, the performance of solely direct temporal simulations requires significantly hi...

Steady-state enzyme kinetics is a cornerstone technique of biochemistry and related sciences since it allows the characterization quantification behaviour. Enzyme widely used to investigate physiological role enzymes, determine effects mutations characterize inhibitors. Well-known examples inhibitors treat diseases include anti-infectives (e.g., penicillin, clavulanic acid HIV protease inhibito...

The empirical literature provides a wide range of estimates for trade elasticities at the aggregate level. Furthermore, recent contributions in international macroeconomics suggest that low (implied) values of the trade elasticity of substitution may play an important role in understanding the disconnect between international prices and real variables. However, a standard model of the internati...

sickle cell disease is a genetic haemoglobinopathy with consequent haemolysis and anaemia. it is of interest to study its effect on red cell indices beside haemoglobin concentration.the objective of the study is to determine the values of red cell indices in preschool-age children with sickle cell anaemia.we conducted a cross-sectional study including 97 children with sickle cell anaemia aged s...

background: sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. the purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. methods: a cross-sectional study was conducted among the sickle cell patients atten...

This paper studies the nonlinear vibration analysis of a simply supported Euler-Bernoulli beam resting on a nonlinear elastic foundation under compressive axial load using nonlinear normal modes concept in the case of three-to-one (3:1) internal resonance. The beam’s governing nonlinear PDE of motion and also its boundary conditions are derived and then solved using the method of Multiple Time ...