Diabetes mellitus is a complex multifarious metabolic disorder characterized by chronic hyperglycemia that requires non-stop treatment with multiple factors will reduce the risk of long-term complications and drug side effects. Streptozotocin well known for its selective pancreatic islet β-cell cytotoxicity used to induce diabetes in animals. It also interferes cellular oxidative mechanisms. Ph...

objective: as the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of cs in diabetic mice.materials and methods: both single and repeated oral administrations of aqueous extract of cs were performed in multi-low dose streptozotocin-induced (mlds) diabetic mice. euglycemic hyperinsulinemic clamp was used in as...

today diabetes is one of the most common diseases in the world that affects half of the world population. today, the use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. so, this study was conducted to evaluate the effect of cinnamon and green tea extract,...

Low-dose streptozotocin-induced diabetes in mice serves as a model of type I diabetes. Suppression of the development of diabetes (hyperglycemia) in C3H/He mice was achieved with in vivo administration of antibody reactive to Ir-gene products before streptozotocin treatment. A persistent effect was reached with two monoclonal antibodies directed against I-Ak gene products and, surprisingly, by ...

Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship b...

Although diabetic cardiomyopathy is associated with enhanced intramyocardial triacylglycerol (TAG) levels, the role of TAG catabolizing enzymes in this process is unclear. Because the TAG hydrolase, adipose triglyceride lipase (ATGL), regulates baseline cardiac metabolism and function, we examined whether alterations in cardiomyocyte ATGL impact cardiac function during uncontrolled type 1 diabe...

This study examines possible interactions between behavioral effects and influence of N-methyl-D-aspartate acid (NMDA) receptors in 4 and 12-week streptozotocin (STZ) induced diabetic rats. Effects of NMDA receptor agonist on spatial learning were tested in control groups of rats and in rats with 4 and 12 weeks diabetes mellitus (DM). Experimental diabetes was induced by a single intravenous in...

Aims : The present study evaluates the antidiabetic activity of Swertia chirata (aqueous extract) on the blood glucose level of streptozotocin induced diabetic rat models. Objectives : i) To study the antidiabetic activity of aqueous extract of Swertia chirata in streptozotocin induced diabetes in albino rats. ii) To compare the antidiabetic activity of Swertia chirata extracts with that of sta...