We study statistical properties of interacting protein-like surfaces and predict two strong, related effects: (i) statistically enhanced self-attraction of proteins; (ii) statistically enhanced attraction of proteins with similar structures. The effects originate in the fact that the probability to find a pattern self-match between two identical, even randomly organized interacting protein surf...

Protein kinases play a crucial role in cell signaling and are important drug targets in several therapeutic areas. The KLIFS database contains detailed structural kinase-ligand interaction information derived from all (>2900) structures of catalytic domains of human and mouse protein kinases deposited in the Protein Data Bank in order to provide insights into the structural determinants of kina...

EB1 proteins bind to microtubule ends where they act in concert with other components, including the adenomatous polyposis coli (APC) tumor suppressor, to regulate the microtubule filament system. We find that EB1 is a stable dimer with a parallel coiled coil and show that dimerization is essential for the formation of its C-terminal domain (EB1-C). The crystal structure of EB1-C reveals a high...

Latrophilins, receptors for spider venom α-latrotoxin, are adhesion type G-protein-coupled receptors with emerging functions in synapse development. The N-terminal region binds the endogenous cell adhesion molecule FLRT, a major regulator of cortical and synapse development. We present crystallographic data for the mouse Latrophilin3 lectin and olfactomedin-like (Olf) domains, thereby revealing...

Human ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that prevents protein degradation by removing polyubiquitin chains from its substrates. It regulates stability of a number of human transcription factors and tumor suppressors and plays a critical role in the development of several types of cancer, including prostate and small cell lung cancer. In addition, human USP7 is ta...

Engineer–computer interaction ~ECI! is a new subdomain of human–computer interaction that is specifically tailored to engineers’ needs. ECI uses an information classification schema, provides a modular approach to task decomposition, and integrates standard engineering characteristics and working procedures into software. A software tool kit that interprets monitoring data taken from bridges wa...

in this paper effect of pile-soil consideration in obtaining seismic response offshore structure is assessed due to earthquake loading. inducedseismic force is one of the most important excitations for the dynamic response of an offshore structure. according to api, seismic forces should be accounted in platform design for seismically active regions in order to determine the allowable seismic r...

1. I n t r o d u c t i o n Several focal issues have emerged in machine translation (MT) research as the result of recent intensive studies in the field. Tha t is, • Declarative Frameworks for expressing Bi-lingual Knowledge • Integration of Knowledge-based Processing and Contextual Processing with the Translation Process • Effective Exploitation of Domain /Tex t Type Specificity (or Sublanguag...

This paper discusses coml)lex s t ructural changes during transfer within a non-destructive transfer framework. Though the description of each individual s t ructural change is not difficult, special provision must be made when they are combined, because interaction between them sometimes causes unexpected problems. Transfer of coordinate structures is also discussed a.q this sometimes necessit...