Objective(s):Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (TGF-β). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFβ1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...

Podocyte injury contributes to renal damage and, eventually, to the occurrence of proteinuria in diabetic nephropathy. The aim of the present study was to investigate the effect of an ethanol extract from Rhizoma Polygonum cuspidatum (P. cuspidatum) on proteinuria and podocyte injury, and elucidate the underlying mechanism for streptozotocin (STZ)‑induced diabetic nephropathy. The protective ef...

To study the effect of okra aqueous extract on intestinal flora diabetic rats. Taking normal SD rats as CK group, induced by 40 mg/(kg•bw) streptozotocin (STZ) intraperitoneally M and gavaged with 500 were CKO MO groups,respectively. The bacterial cecum contents was analyzed 16S rRNA V3-V4 sequencing after 8 weeks experiment. Compared CK, increased Firmicutes 14.00% decreased Proteobacteria 19....

Objective: The aim of the current study was to investigate the protective effect of Artemisia turanica (AT) against diabetes- induced renal oxidative stress in rats. Materials and Methods: Fifty male Wistar rats were randomly divided into five groups: control, STZ-induced diabetic rats, diabetic rats+ metformin, diabetic rats + AT extract, diabet...

Diabetic nephropathy (DN) is a major cause of end-stage renal disease in the general population. It estimated that DN will eventually develop about 40% all patients with diabetes; therefore, prevention critical for delaying development and progression diabetic kidney disease. Despite extensive efforts, medical advances are still not successful enough to prevent In present study, we focused on c...

The aim of this study was to investigate the effects of ethanolic extract of the whole plant of Phyllanthus rheedii wight P.rheedii as antihyperglycemic, antihyperlipidemic and antioxidant effect in streptozotocin (STZ) induced diabetic rats. Male Wistar rats were administered P.rheedii (250 mg/kg) orally for 21 days and blood glucose level was measured weekly. At the end of 21 days, the serum ...

BACKGROUND Water extract from the root of Allium hookeri (AH) shows anti-inflammatory, antioxidant, and free radical scavenging effects. In this study, the ameliorating effects of AH on oxidative stress-induced inflammatory response and β-cell damage in the pancreas of streptozotocin (STZ)-induced type 1 diabetic rats were investigated. METHODS AH (100 mg/kg body weight/day) was orally admini...

Background: In this study, the anti-diabetic effect of the extract of leaves and fruits of Avicennia marina (A. marina) in streptozotocin (STZ)-induced diabetic male rats was investigated. Methods: An experimental study was conducted on 45 adult male rats in 9 groups of 5 rats. The control group received normal food only. Other groups were made diabetic by injecting them with 60 mg/kg intrap...

Using superior mesenteric artery rings isolated from age-matched controls and streptozotocin (STZ)-induced diabetic rats, we recently demonstrated that EDHF-type relaxation is impaired in STZ-induced diabetic rats, possibly due to a reduced action of cAMP via increased phosphodiesterase (PDE) activity (Matsumoto T, Kobayashi T, and Kamata K. Am J Physiol Heart Circ Physiol 285: H283-H291, 2003)...