This paper proposes a method for sensing affinity interactions by triggering disruption of self-assembly of ion channel-forming peptides in planar lipid bilayers. It shows that the binding of a derivative of alamethicin carrying a covalently attached sulfonamide ligand to carbonic anhydrase II (CA II) resulted in the inhibition of ion channel conductance through the bilayer. We propose that the...

Essential oils (EOs), as unique natural products, are promising resources for the discovery of green agrochemicals. The main ingredient geraniol citronella oil was found to exhibit substantial antifungal activities in this study. Therefore, a series novel geranyl aromatic sulfonamide compounds were synthesized and display considerable activities. Two thiofuran-sulfonamide 4c-1 (median effective...

BACKGROUND The red fluorescent dye Sulforhodamine 101 (SR101) has been used in neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this work is to label SR101 with positron emission radionuclides, in order to provide a radiotracer to study its biological behavior. This is the first...

Lack of correlation between quantitative minimal inhibitory concentration (MIC) determinations and disk diffusion susceptibility tests in our laboratory prompted a study to reevaluate the use of the disk diffusion test for sulfonamide susceptibility testing of Neisseria meningitidis. One hundred and sixty-three recent clinical isolates of N. meningitidis were examined for sulfonamide susceptibi...

Sulfonamide gehören zu den wichtigsten funktionellen Gruppen in Pharmazeutika und Agrochemikalien. Es gibt jedoch keine Methode, um die Sulfonamidgruppe direkt eine nicht vorfunktionalisierte aromatische Verbindung einzuführen. Wir stellen hier das erste dehydrierende elektrochemische Verfahren zur Synthese von Sulfonamiden vor, indem inhärente Reaktivität (Hetero)arenen einer hochkonvergenten ...

A total of 116 Escherichia coli isolates from cecal contents 81 indigenous wild birds in Korea were tested for antimicrobial susceptibility. Seventy-one sparrows (Passer montanus) and one isolate doves (Columba livia) resistant to three antimicrobials, including streptomycin, sulfonamide, tetracycline (SSuT). PCR subsequent sequence analysis revealed the SSuT gene cluster region (approximately ...

In the title compound, C9H8N2O2S, the sulfamoyl -NH2 group is involved in inter-molecular hydrogen bonding with the sulfonamide O and quinoline N atoms. In the crystal, mol-ecules are linked into dimers via pairs of N-H⋯N hydrogen bonds, forming an R 2 (2)(10) motif. The dimers are further assembled into chains parallel to the b axis through N-H⋯O hydrogen bonds, generating a C(4) motif. The cr...