Diarylpentanoids exhibit a high degree of anti-cancer activity and stability in vitro over curcumin prostate cancer cells. Hence, this study aims to investigate the effects diarylpentanoid, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (MS13) on cytotoxicity, anti-proliferative, apoptosis-inducing, anti-migration properties, underlying molecular mechanisms treated androgen-independent...

Prostate cancer is the most common and second leading cause of death among men in the world. Nowadays, radiotherapy has been known as one of the most affecting methods for prostate cancer treatment. Nevertheless, radiotherapy is accompanied by the concern of developing secondary cancers by the scattered radiation to the neighbor  organs at risk. Several studies have shown that secondary cancers...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

SCOPE Epidemiological studies provide evidence that consumption of cruciferous vegetables, like broccoli, can reduce the risk of cancer development. Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that induces anti-proliferative and pro-apoptotic responses in prostate cancer cells, but not in normal prostate cells. The mechanisms responsible for this cancer-specific cy...

Purpose:During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer or metastatic castrate-resistant prostate cancer (mCRPCa) to establish clinical relevance. The effect of glutamate deprivation or blockade by metabotropic glutamate receptor 1 (GRM1) antagonist...

abstract   background: regarding the variety of tests present for detecting and also screening prostate cancer and also bearing in mind the advantages and disadvantages of these tests we decided to re-evaluate these tests (total prostate specific antigen and all of its modifications) in detecting prostate cancer in men with intermediate serum psalevels.   methods: following a cross sectional st...

Aims: To investigate the effect of parthenolide on nucleolin in controlling expression miR-375 that induces apoptosis and cell cycle arrest prostate cancer.
 Study Design: This study is an experimental study.
 Methodology: The cytotoxicity was tested by MTT assay for 48 h. Microscopic techniques were used to identify morphological changes line. apoptotic regulatory genes analyzed Real...

conclusions the best balance between detection rate of prostate cancer and infectious complications of biopsies achieved in twelve-core biopsy protocol. twelve-core biopsy enhances the rate of prostate cancer detection with minimum adverse effects. patients and materials transrectal ultrasonography (trus) guided biopsy was performed in 180 patients suspicious for prostate cancer due to either a...