Temperature and pH responsiveness is important for biological applications in protein reconstitution, gene delivery and controlled drug release. The temperature and pH dual responsive self-assembly transition, vesicle-to-micelle transitions (VMTs) and micelle-to-vesicle transitions (MVTs), in dodecyl sulfonatebetaine (DSB)/sodium bis(2-ethylhexyl) sulfosuccinate (AOT) aqueous solution are inves...

Recently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative diseases. However, the evolution of stimuli-responsive vesicles from bench to bedside still seems far away for the limitations of current stimuli forms such as temperature, light, redox, etc. Since ultrasound combined...

Injectable "smart" microspheres that are sensitive to both temperature and pH have been fabricated and tested for controlled delivery of therapeutic proteins to ischemic skeletal muscle. A library of copolymers composed of N-isopropyl acrylamide (NIPAAm), propyl acrylic acid (PAA), and butyl acrylate (BA) was used to fabricate microspheres using a double emulsion method, and an optimal formulat...

In the last decade, nanobiotechnology has evolved rapidly with an extensive impact on biomedical area. In order to improve bioavailability and minimize adverse effects, drug delivery systems based on magnetic nanocomposites are under development mainly for cancer imaging and antitumor therapy. In this regard, pH sensitive core-shell magnetic nanoparticles (NPs) with accurate controlled size and...

Introduction In recent years, there has been a great interest in the fabrication of stimuli responsive polymer microspheres for technological application and fundamental studies. These stimuli responsive smart and intelligent polymeric materials can respond in shape or volume changes to small external stimuli such as temperature, pH and ionic strength etc [1, 2]. Among these stimuli responsive ...