In recent years, a number of studies had been done on the issues of fastest navigation path planning due to wide applications. Most of previous studies focused on the fastest path planning by mining historical traffic logs. However, the real time traffic situations in the road network always vary continuously due to the occurrences of traffic events. Therefore, a better planning strategy should...

Si la investigación reciente explora el carácter plural del “reformismo borbónico”, en península o las Indias, cambio, suele considerarse que se enfrenta a una oposición monolítica cuya postura resume defensa interesada de tradición. Esta es lectura usual “Dictamen reservado” conde Tepa rechazó, 1773, proyecto intendencias forjado por José Gálvez para Nueva España 1768. Critico esta interpretac...

Treatment with three daily doses (3-10 gg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments. In tumors from mice having other treatment schedules and in livers from all groups no definite change ...

Pentoxifylline potentiates the cytotoxicity of alkylating agents in preclinical models. In this study we sought to define the maximum tolerated dose (MTD) of N,N’,N”triethylenethiophosphoramide (thioTEPA) with pentoxifylline, and to estimate the antitumor response to this combination in previously treated breast cancer patients. Thirtyfive previously treated advanced breast cancer patients rece...