OBJECTIVES We have demonstrated epigenetic modulation of CD34(+) cell differentiation by the high-affinity copper (Cu) chelator tetraethylenepentamine (TEPA). TEPA slowed down the rate of CD34(+) cell differentiation and increased their engraftability in SCID mice. TEPA biological activity was attributed to its effect on cellular Cu levels as (a) treatment with TEPA resulted in reduction of cel...

In order to test the effect of selenium on the anticancer activity of alkylating drugs, Seleno-TEPA (4), the selenium analog of the clinically used Thio-TEPA (1) was tested in vivo against the lymphocytic P 388 and lymphoid L1210 murine leukemias. Compound 4 is more active against P 388 leukemia than against L1210, and appears to be active over a narrower concentration range than Thio-TEPA (1)....

Oxidative degradation characteristics of silica-supported amine sorbents with varying amounts of tetraethylenepentamine (TEPA) and polyethylene glycol (PEG; P(200) or P(600) represents PEG with molecular weights of 200 or 600) have been studied by IR and NMR spectroscopy. Thermal treatment of the sorbents and liquid TEPA at 100 °C for 12 h changed their color from white to yellow. The CO(2) cap...

Dietary mono- or di-trans fatty acids with chain lengths of 18-22 increase the risk of cardiovascular diseases because they increase LDL cholesterol and decrease HDL cholesterol in the plasma. However, the effects of trans isomers of PUFAs on lipid metabolism remain unknown. Dietary PUFAs, especially eicosapentaenoic acid (EPA) in marine oils, improve serum lipid profiles by suppressing liver X...

Signal peptides direct the export of secretory proteins from the cytoplasm. After processing by signal peptidase, they are degraded in the membrane and cytoplasm. The resulting fragments can have signaling functions. These observations suggest important roles for signal peptide peptidases. The present studies show that the Gram-positive eubacterium Bacillus subtilis contains two genes for prote...

Two types of lanthanide selenidostannates(iv) [Ln2(tepa)2(μ-OH)2Sn2Se6] {Ln = Y(), Pr (), Dy (), Er (), Tm (); tepa = tetraethylenepentamine} and [Ln2(tepa)2(μ2-OH)2Cl2]2[Sn4Se10]·4H2O {Ln = Y (), Dy (), Er (), Tm ()} have been synthesized under identical solvothermal conditions and characterized structurally. Type I (, , , and ) displays 1-D neutral chains [Ln2(tepa)2(μ-OH)2Sn2Se6]n, while typ...

One novel 1-D europium thioindate-thioantimonate {[Eu(tepa)](2)[μ(2)-SbS(3)](μ(2)-H(2)O)}[Eu(tepa)In(4)S(9)]·0.25tepa (1, tepa = tetraethylenepentamine) has been solvothermally synthesized. 1 represents the first example of the coordination of a soft Lewis basic 1-D polymeric [In(4)S(9)(6-)](n) ligand to a hard Lewis acidic Eu(3+) ion. The wide-band-gap semiconductor and photoluminescence prope...

Two novel lanthanoid thioantimonates [Sm(4)(tepa)(4)(μ-η(2),η(3)-Sb(3)S(7))(2)(μ-Sb(2)S(4))] (1, tepa = tetraethylenepentamine) and [Eu(2)(tepa)(2)(μ-SbS(3))(μ-OH)](2)(SbS(4))(OH)·H(2)O (2) were solvothermally synthesized. Compound 1 represents the only example of different types of [Sb(3)S(7)](5-) and [Sb(2)S(4)](2-) anions coexisting in the same lanthanoid thioantimonate framework, while 2 di...

We have previously found that the synthetic polyamine tetraethylenepentamine (TEPA) significantly delayed differentiation and prolonged expansion of cord-blood derived HPC in cytokine-supplemented cultures. Most HPC have the CD34+CD38+ phenotype, but the minority CD34+38- cells are primitive subset of HPC that have the potential for long-term repopulation in vivo. We investigated the effect of ...

By comparing with the American CAEP teacher education accreditation standard, we study characteristics of Chinese professional (TEPA) and differences between standards. The aim TEPA, which is drawing lessons from idea engineering accreditation, to improve overall quality teachers team, ensure education, make pre-service cultivation institutions continue improve, meet needs society for qualified...