نتایج جستجو برای: therapeutic antibody
تعداد نتایج: 505122 فیلتر نتایج به سال:
Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid- CETP peptide (TT-CETP) was mixe...
Growing numbers of therapeutic antibodies offer excellent treatment strategies for many diseases. Elucidation of the interaction between a potential therapeutic antibody and its target protein by structural analysis reveals the mechanism of action and offers useful information for developing rational antibody designs for improved affinity. Here, we developed a rapid, high-yield cell-free system...
Antibodies play an essential role in modern medicine for diagnostic and therapeutic applications. Even though the production of antibodies is fastest growing pharmaceutical industry area, cost remains high, which limits access to antibody-based both developing developed countries. The bottleneck major factor purification antibody. Here, a proof-of-concept presented antibody extraction using fer...
Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about validity some co...
Abstract There is an unmet need to identify novel targeted therapies for H3K27M mutated Diffuse Midline Gliomas. (DMG) Using genetic overexpression and deletion of in model cells we identified high expression CD99 mRNA H3K27M-mutant expressing DIPGs compared other normal brain counterparts. A cell surface antigen screen confirmed that was highly expressed DMG tissues. We then developed a chimer...
paraneoplastic cerebellar degeneration is a rare, fatal neuronal syndrome associated with ovarian, breast and lung cancers. anti-yo antibody mediated paraneoplastic cerebellar degeneration is known to be associated with gynecological malignancies, especially ovarian cancer. however, there are no reports of anti-yo antibody associated predominant peripheral mixed sensory and motor neuropathy in ...
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