The lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders (mixed connective tissue disease, systemic vasculitis, polyarteritis nodosa, primary sicca syndrome, discoid lupus, Behcet's syndrome, and systemic sclerosis). Strong associations were found with biological false positive seroreaction for syphilis and thro...

Fibrinogen, one of the most hemorheologically active plasma proteins, is associated with several cardiovascular risk factors, and the plasma concentration can alter dramatically during acute phase response and in a wide variety of clinical conditions. We have assessed fibrinogen levels in some known cardiovascular disorders, during usage of contraceptive pills, acute phase conditions and pregna...

Immune thrombocytopenia (ITP) comprises a heterogeneous group of disorders characterized by autoimmunemediated platelet destruction and impairment of platelet production. Thromboembolic events have been reported in up to 8% of patients with ITP, suggesting that thromboembolism requires special precaution in this patient group. Thromboembolism can be caused by a disease (i.e. pro-thrombotic dise...

Inferior vena cava (IVC) filters are used as an alternative to anticoagulants for prevention of fatal pulmonary embolism (PE) in venous thromboembolic disorders. Retrievable IVC filters have become an increasingly attractive option due to the long-term risks of permanent filter placement. These devices are shown to be technically feasible in insertion and retrieval percutaneously while providin...

Patients with liver diseases have a higher risk of hemostatic disorders. Meanwhile, despite well-established opinion on low thromboses in cirrhosis, thromboembolic events cannot be totally ruled out these patients. Increased risks thrombotic and venous thromboembolism cirrhosis are accounted for by external (immobilization, surgeries, infections, comorbidities) internal factors (reduced synthes...

Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestation...

ting of hematologic disorders like sickle-cell anemia, leukemia, lymphoma, polycythemia vera and hypercoagulable states like protein C, protein S deficiencies due to clogging of the splenic microcirculation by abnormal cells1. Other conditions include thromboembolic phenomenon like infective endocarditis, atrial fibrillation and postcardiac surgery. In malaria, splenic infarction is a rare comp...

Anticoagulant and antiplatelet agents are indicated in the prevention and treatment of a variety of thromboembolic disorders. Antiplatelet agents predominately effect the development of clot formation in the arterial circulation, where platelets play a more pivotal role than in the venous circulation. Anticoagulants affect clot formation in both the arterial and venous circulation by inhibiting...

Venous thromboembolism (VTE) is a multifactorial disease. Major provoking factors (e. g. surgery, cancer, major trauma, and immobilisation) are identified in 50-60 % of patients, while the remaining cases are classified as unprovoked. However, minor predisposing conditions may be detectable in these patients, possibly concurring to the pathophysiology of the disease, especially when co-existing...