From the Medical Oncology Department, Translational Research Unit, Jules Bordet Institute, Université Libre de Bruxelles, Brussels (C.S.); and the Department of Breast Medical Oncology, the University of Texas M.D. Anderson Cancer Center, Houston (L.P.). Address reprint requests to Dr. Sotiriou at the Translational Research Unit, Jules Bordet Institute, 121 Blvd. de Waterloo, Brussels 1000, Bel...

Translational medicine is a branch of medical research that attempts to more directly connect basic research to patient care. Translational medicine is growing in importance in the healthcare industry. In the case of drug discovery and development, translational medicine typically refers to the “translation” of basic research into real therapies for real patients. The emphasis is on the linkage...

Translational medical research is an emerging concept that aims at transforming discoveries from basic sciences into diagnostic and therapeutic applications. In the opposite direction, clinical data are needed for feedback and as stimuli for the generation of new research hypotheses. This process is highly data-intensive and centered around the idea of integrating data from basic biomedical sci...

Personalized treatment using stem, modified or genetically engineered, cells is becoming a reality in the field of medicine, in which allogenic or autologous cells can be used for treatment and possibly for early diagnosis of diseases. Hematopoietic, stromal and organ specific stem cells are under evaluation for cell-based therapies for cardiac, neurological, autoimmune and other disorders. Cyt...

1 Laboratory of Translational Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy 2 Institution of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Wales, UK 3 Translational Tumor Immunology Group, Ludwig Center for Cancer Research, Epalinges, Switzerland 4 Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano,...

There is a growing consensus that the transfer of knowledge from biomedical discoveries into patient and public benefit should be accelerated. At the same time there is a persistent lack of conceptual clarity about the precise nature of the phases of the translational continuum necessary to implement this. In this paper, we: (i) propose an integrated schema to understand the five sequential pha...

BACKGROUND The Liaison Committee on Medical Education notes the importance of educating medical students on clinical and translational research principles. PURPOSE To describe a fourth-year course, "Process of discovery," which addresses teaching these principles, and to discuss students' perceptions of the course. METHODS Core components and pedagogical methods of this course are presented...