نتایج جستجو برای: translational medical research

تعداد نتایج: 1934125  

Journal: :asia pacific journal of medical toxicology 0
jeffrey brent department of internal medicine (clinical pharmacology and toxicology), school of medicine, university of colorado, denver, co, usa

although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. the development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. interest in the development of fomepizole was spurred in the 1960s. shortly t...

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

2013
A Anastasio A Armenante A Gimigliano A Moscarino S Panzera R Romano I Russo G Scarpati

Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the fundamental vision of Translational Medicine, which efficiently and effectively translates basic scientific findings relevant to human disease into knowledge that benefits patients...

Journal: :Anais da Academia Brasileira de Ciencias 2015
Meina Li Lulu Zhang

Globally, one of the major trends is the development of translational medicine. The traditional hospital structure could not meet the demands of translational medicine development any longer and to explore a novel hospital structure is imperative. Following the times, China proposed and implemented a development strategy for a first-class modern research-oriented hospital. To establish a resear...

Journal: :Biopreservation and biobanking 2015
Xiaopan Liu Qiyuan Li Xian Wang Xiaolin Zhou Qiuyan Liao Xuheng He Jiuling Zhang Jianbo Sun Jinhua Wu Le Cheng Yong Zhang

Human blood specimens serve as important research materials in the field of translational medicine research. The RNA extracted from blood, for example, represents the gene expression profiles of individuals or groups, and can be indicative of the pathological basis for human diseases. Meanwhile, the RNA quality may have severe impacts on the results of RNA studies. RNA is susceptible to many fa...

Journal: :Biomedical and environmental sciences : BES 2013
Kai Lu Tao Chen Yu Chen George F Gao

Journal: :Neurology 2014
Stefan Rose-John Ralf Gold

2015
Les Jordan

Understanding the parallel evolutions of Big Data and Translational Medicine, and the types of disruptive technology that bring them together, requires a look back at their evolution and a discussion of the hindrances in applying big data techniques to translational medicine. We will then take a look into the future, at the concept of the "Complete Health Record" and how that may change the ver...

2014
Stefanie Dimmeler Céline Carret Roberto Buccione

These are exciting times for translational medicine as the convergence between fundamental and clinical research comes of age. The new EMBO Press publishing platform reinforces the standing of EMBO Molecular Medicine as the journal that matches high quality, novel research with rigorous editorial and ethical standards. It will also cement the journal's global reach and relevance whether in high...

2010
R. John Solaro

This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle. I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection. Data are presented supporting the idea that processes intrinsic to the t...

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