angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

Abstract Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress poor osteogenesis peri-implant bone area. Genipin is major component gardenia fruits with strong antioxidant, anti-inflammation, antidiabetic actions, it also can activate ...

Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. Due to the anti-diabetic and antioxidant activity of pelargonidin (PG), this research study was conducted to evaluate the efficacy of chronic oral PG on alleviating learning and memory disturbance in streptozotocin-diabetic rats. Male Wistar rats were divided into...

Background: The study was performed to the alterations in biochemical markers of liver and kidney function oxidative stress indices on sub-acute exposure meloxicam albino rats. Methods: three groups rats, consisting six rats each group. group I were served as control. However, II, III treated with @ 0.2 mg/kg b.wt. 0.6 respectively. Result: Meloxicam administration induced indicated by signific...

intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of crocus sativus l. extract (cse) was evaluated on icv stz-induced learning, memory, and cognitive impairment in male rats. for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the stz-injected rats received cse (60 mg/kg; i.p.) every o...

background: danae racemosa is a strong antioxidant and antioxidants have significant effects on spermatogenesis, sperm biology and oxidative stress, and changes in antioxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. objective: because stz causes testicular dysfunction and degeneration under situations of experimentally induced diabetes in animal ...

background and objective: intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of saffron main component, safranal was investigated on icv stz-induced learning, memory, and cognitive impairment in male rats. materials and methods: for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the st...

background: tissue protective effect of compounds with antioxidant properties has been demonstrated. the alkaloids found in barberry root are considered as antioxidants. objective: according to barberry protective effects in different tissues, in this study, the protective effect of berberis integerrima bge. root )mebir) was evaluated against ccl4-induced testicular damages in wistar rats. mate...

Background: Electromagnetic radiation (EMR) is responsible for many hazardous impacts on living organisms. We aimed to investigate the effects of EMR on kidney tissue in rats in order to predict possible effects on human kidneys and to study the radioprotective effect of ferulic acid (FA). Materials and Methods: Six rats were used as controls, six rats were used as treated group with FA, six ra...

objective(s) in recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. so, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult wistar rats. materials and methods thirty two adult wistar rats were randomly divided in four equal experiment groups; oil ...