Mohsen Khalili
Neurophysiology Research Center, Shahed University, Tehran, Iran
[ 1 ] - Antioxidant and Antiepileptic Activity of 1-[1-(3-Methoxyphenyl) (Tetralyl)] Piperidine as a New Derivative of Phencyclidine on Pentylentetrazole-Induced Kindling Mice
Background and Objective: N-Methyl-D-aspartate (NMDA) antagonists such as piperidines are the most important antiepileptic drugs. Considering the fact that piperidine derivatives such as phencyclidine (PCP) and its new derivative, 1-[1-(3-methoxyphenyl) (tetralyl)] piperidine (PCP1), have different potencies, the antiepileptic effects of mentioned drugs were investigated in the present study. ...
[ 2 ] - Behavioral and Histological Analysis of Crocus sativus Effect in Intracerebroventricular Streptozotocin Model of Alzheimer Disease in Rats
Background and Objectives: There is well established the beneficial effects of Crocus sativus extract in learning and memory improvement. In the present study the effect of this plant in memory behavioral impairment and forbrain histological damage induced by STZ-icv model of Alzheimer disease were investigated. Materials and Methods: This study was conducted at Shahed University (...
[ 3 ] - Neuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
[ 4 ] - Antiepileptic and Antioxidant Effect of Brassica nigra on Pentylenetetrazol-Induced Kindling in Mice
Considering the high rate of epilepsy today, with respect to the insufficiency of the available therapies, new strategies and methods are recommended for medical treatment of epileptic patients. Therefore, the present study experimentally investigated the anticonvulsant effect of a herbal medicine candidate brassica nigra, by using kindling method. Sixty male mice were randomly selected and div...
[ 5 ] - Chronic Oral Pelargonidin Alleviates Learning and Memory Disturbances in Streptozotocin-Diabetic Rats
Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. Due to the anti-diabetic and antioxidant activity of pelargonidin (PG), this research study was conducted to evaluate the efficacy of chronic oral PG on alleviating learning and memory disturbance in streptozotocin-diabetic rats. Male Wistar rats were divided into...
[ 6 ] - Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...
[ 7 ] - Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats
Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...
[ 8 ] - Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats
Background and Objective: Electroconvulsive therapy (ECT) is the end choice treatment for patients with major depressive disorder (MDD). Regarding researches that show NMDA receptor inactivation could yield the same results as anti-depressant drugs, however, the present study examined co-administration of ECT and ketamine (as NMDA antagonist) on depressed rat behaviors. Materials and Methods...
[ 9 ] - L-carnosine Improves Short-Term Spatial Recognition Memory and Passive Avoidance Learning and Memory in Streptozotocin-Diabetic Rats
Background and Objective: Diabetes mellitus (DM) affects synaptic plasticity in the hippocampus, leading to impairments in learning and memory. L-carnosine, an endogenous dipeptide, is reported to exhibit anti-diabetic and antioxidant effects. Therefore, this study was designed to evaluate its effect on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wis...
[ 10 ] - The effect of methadone and haloperidol combination on anxiety induced by morphine withdrawal in male mice
Background and Objective: Regarding inefficiency of common drugs used for alleviation of anxiety due to narcotics withdrawal, the present study was evaluated methadone and haloperidol co-drugs therapy on anxiety due to morphine withdrawal. Materials and Methods: Ninety eight NMRI male mice were divided into acute and chronic experimental groups. Then, each group was divided into 7 subgroups: sa...
[ 11 ] - Ellagic acid attenuates enhanced acetylcholinesterase reactivity in an experimental model of Alzheimer′s disease induced by beta amyloid25-35 in the rat
Background and Objective: Alzheimer’s disease (AD) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. With regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of Alzheim...
[ 12 ] - Antinociceptive Effect of Oral and Intraperitoneal Administration of Alcoholic Viscum Album Fruit Extract in Male Rats
Objective: The present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic Viscum album (V.A) fruit extract as a rich source of alkaloid substances. Materials and Methods: Experimented animals were divided into control and treatment groups. The treatment rats received different doses of the V.A fruit extract, which was prepared from alcoholic sma...
[ 13 ] - Synthesis and Study of Anti-convulsive Effect of 1-[1-(4-Methylphenyl) (Cyclohexyl)] 4-piperidinol as a New Derivative of Phencyclidine by PTZ- Induced Kindling Model in Male Mice
Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...
[ 14 ] - Effects of edible and injection use of Ginger in memory and learning in rats
Abstract Background and Objective: According to the importance of learning and memory in the human life and also unavoidable neural degeneration due to aging, finding new compounds (drugs) against this process is valuable. However, there are many recommendations for herbal medicine and constituents which encouraged us to examine a candidate plant Zingiber officinalis for the mentioned purpose. ...
[ 15 ] - Synthesis and study of anticonvulsant effect of 1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol as a new derivative of phencyclidine in PTZ-induced kindling model in male mice
Background and Objective: Epilepsy is a common disease in communities. Since there is no cure for it and current treatments are not effective for every patient, new method for medical treatment of epileptic patients is necessary. As NMDA receptors antagonists are the most prominent anti-epileptic drugs, in this study we synthesized and investigated anti-epileptic effect of a new piperidine deri...
[ 16 ] - Methadone and haloperidol combination effect on the acquisition and expression of morphine tolerance and dependence in male mice
Background and Objective: Today, opioids are used to control and relieve acute and chronic pain. However, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. So, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined. Materials and Methods: Ninety-eight mic...
[ 17 ] - Evaluation of the effect of oral administration of Hab-o Shefa on morphine withdrawal syndrome in rats: a behavioral study
Background and Objective: Traditional Iranian Medicine (TIM) has a long history in the field of diagnosis and treatment of various diseases, particularly addiction. Different therapeutic methods have been recommended in this respect. One of these methods is the replacement of natural narcotics instead of opium. Hab-o Shefa is a natural product of TIM which has been used as an alternative for op...
[ 18 ] - A comparison of acute pain thresholds between the male and female and the effect of alcoholic Datura stramonium seed extract on it
Introduction: Opposite observations about the discrepancy in the pain perception between male and female has been reported. In this regard, pain thresholds among male and female rats in different phases of oestrous cycle were evaluated via tail immersion test. In addition, efficiency of alcoholic extract of datura stramonium as an analgesic plant in the modulation of acute pain threshold has be...
[ 19 ] - Anti-inflammatory effect of alcoholic Urtica dioica extract in male NMRI rats
Background and Objective: Regarding side effects of acute and especially chronic inflammation and incomplete treatment of patients suffering from these side effects, the new and effective strategies are needed. For this purpose, in the present study, we scientifically evaluate an introduced folk herb Urtica dioica, for treatment of inflammation. Materials and Methods: The Sham, control and trea...
[ 20 ] - Neuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
[ 21 ] - Antiepileptic and Antioxidant Effect of Brassica nigra on Pentylenetetrazol-Induced Kindling in Mice
Considering the high rate of epilepsy today, with respect to the insufficiency of the available therapies, new strategies and methods are recommended for medical treatment of epileptic patients. Therefore, the present study experimentally investigated the anticonvulsant effect of a herbal medicine candidate brassica nigra, by using kindling method. Sixty male mice were randomly selected and div...
[ 22 ] - Chronic Oral Pelargonidin Alleviates Learning and Memory Disturbances in Streptozotocin-Diabetic Rats
Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. Due to the anti-diabetic and antioxidant activity of pelargonidin (PG), this research study was conducted to evaluate the efficacy of chronic oral PG on alleviating learning and memory disturbance in streptozotocin-diabetic rats. Male Wistar rats were divided into...
[ 23 ] - Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...
[ 24 ] - بررسی اثر ضد تشنجی عصارۀ آبی-الکلی گیاه عودالصلیب بر تشنجات حاصل از تزریق پنتیلن تترازول در موشهای سوری نر
Background and Objective: Regarding prevalence of epilepsy and inefficiency of the present treatments, this study was done to evaluate anti-epileptic activity of Paeonia officinalis L alcoholic extract as an anti-convulsive herbal candidate. Materials and Methods: In this experimental study, 40 male mice were divided into 1- control 2- valproate 3, 4 and 5 P. Officinalis extract at doses...
[ 25 ] - اثر مصرف خوراکی عصاره الکلی گیاه بوزیدان بر کاهش حافظه ناشی از تزریق داخل بطنی استرپتوزوتوسین در موشهای سفید آزمایشگاهی نر
Background and Objective: Alzheimer’s disease is a prevalent central nervous system disease with no definitive treatment till now. So, in the present study the effect of an important herbal medicine, withania somnifera (Ws), was investigated on progression of Alzheimer’s disease. Materials and Methods: We used intracerebroventricular streptozotocin (STZ) injection as a model for Alz...
[ 26 ] - بررسی اثر ضد تشنجی عصاره الکلی صمغ گیاه آنغوزه (Ferula assa foetida) در کیندلینگ شیمیایی ناشی از پنتیلن تترازول در موش سوری
Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of used treatment, the new strategy and methods for medical treatment of epileptic patients are necessary. Ferula assa foethica (F.foethica) is an important species of medicinal plant that has been used in traditional medicine as an anti-convulsant herb. So the present study has inv...
[ 27 ] - بررسی مصرف خوراکی و تزریق داخل صفاقی عصاره گیاه وج (Acorus calamus L.) بر میزان حافظه و یادگیری در موشهای صحرایی نر
مقدمه: کاهش سطح حافظه و یادگیری در طی گذشت زمان در اثر فاکتورهای مختلف به خصوص پیری مغز تاثیر بسزایی در روند زندگی انسان داشته است. از طرفی کمبود و یا نبود مکانیسمهای پیشگیری و درمان مطالعه بر روی این بیماری را مهم ساخته است. هدف: با توجه به اهمیت طب سنتی و نیز کاندید بودن گیاه وج به عنوان یکی از گیاهان شاخص طب سنتی در جهت تقویت حافظه، در تحقیق حاضر به مطالعه تجربی این مسأله پرداخته شده است. ...
[ 28 ] - بررسی اثر ضدالتهابی عصاره الکلی گیاه گزنه دو پایه در موشهای صحرایی نر از جنس NMRI
مقدمه: التهاب به خصوص نوع مزمن آن از عوارض شایع و آسیبرسان بیماریها است که عدم درمان قطعی و کامل آن توسط داروهای شیمیایی نیاز به تحقیق در زمینه این بیماری را با روشها و داروهای جدید اجتناب ناپذیر کرده است. هدف: در تحقیق حاضر اثر عصاره الکلی یکی از گیاهان سنتی ایران با نام گزنه دوپایه که در کتب قدیم به عنوان گیاه ضد آماس معرفی شده با روشهای علمی در دو مدل مختلف التهاب حاد و مزمن بررسی شده ...
[ 29 ] - اثر ضددردی عصاره الکلی بذر گیاه تاتوره در موشهای صحرایی نر دیابتی ناشی از تزریق استرپتوزوتوسین
مقدمه: دیابت و به خصوص عوارض ناشی از آن که به عنوان یکی از شایعترین بیماریها که در سنین متفاوت و با علل مختلف بروز میکند، افراد درگیر را با مشکلات فراوانی روبرو کرده است. از جمله مهمترین این عوارض افزایش حساسیت به عوامل دردزا (هیپرآلژزی) و در بعضی موارد افزایش آستانه درد (آلودینیای ناشی از نوروپاتی) را میتوان نام برد. براین اساس در تحقیق حاضر در ابتدا آستانه درد حاد و مزمن موشهای دیابتی به...
[ 30 ] - بررسی اثرات عصاره الکلی ریزوم گیاه زنجبیل بر میزان درد و التهاب حاد و مزمن در موش سفید بزرگ آزمایشگاهی
سابقه و هدف: روشهای درمانی جایگزین برای درمان بیماریهای مزمن و دردناک اهمیت زیادی دارد. گیاه زنجبیل در غذاهای مردم دنیا استفاده می شود و عصاره آن، واجد فعالیت های فارماکولوژیک زیادی است. هدف تحقیق کنونی، بررسی اثرات عصاره الکلی زنجبیل روی دو مدل مختلف التهاب و درد حاد و مزمن بود. مواد و روش ها: برای ایجاد التهاب حاد از تزریق فرمالین به کف پای حیوان، تزریق گزیلن به گوش و اسیداستیک بهداخل...
[ 31 ] - بررسی اثر عصاره الکلی گیاه انجره بر التهاب حاد و مزمن در موشهای صحرایی نر از جنس NMRI
سابقه و هدف: التهاب از جمله عوارض بسیاری از بیماریهای شایع و آسیبرسان است که عدم وجود درمان قطعی و کامل آن توسط داروهای شیمیایی، نیاز به تحقیق در زمینه این بیماری را با روشها و داروهای جدید اجتنابناپذیر کرده است. بدین منظور در تحقیق حاضر اثر عصاره الکلی یکی از گیاهان سنتی ایران با نام انجره که در کتب قدیم به عنوان گیاه ضدآماس معرفی شده با روشهای علمی سنجش و بدین منظور اثر بخشی این گیاه در ...
[ 32 ] - اثر عصاره آبی زعفران بر کاهش حافظه ناشی از تزریق داخل بطنی استرپتوزوتوسین در موش صحرایی نر
چکیده مقدمه: با توجه به شیوع و اهمیت درمان بیماریهای دستگاه عصبی مرکزی از جمله زوال مغز مثل آلزایمر و نبودن درمان قطعی برای این بیماری و نیز توصیه طب سنتی بخصوص گیاه درمانی در درمان اینگونه بیماریها، در مطالعه اخیر به بررسی یکی از گیاهان سنتی مؤثر بر حافظه و یادگیری در درمان این بیماری پرداخته شده است. هدف: بررسی اثر عصاره آبی زعفران بر کاهش درک حافظه و یادگیری ناشی از تزریق داخل بطن مغز...
[ 33 ] - اثر ضد التهابی عصاره الکلی بذر گیاه داتوره در موشهای صحرایی نر
زمینه : عدم درمان قطعی و کامل التهاب توسط داروهای شیمیایی، نیاز به تحقیق در این زمینه را با روشها و داروهای جدید اجتنابناپذیر کرده است. هدف : مطالعه به منظور تعیین اثر ضد التهابی عصاره الکلی بذر گیاه داتوره بر التهاب حاد و مزمن در موش انجام شد. مواد و روشها : در این مطالعه تجربی که در سال 1383 در دانشکده پزشکی دانشگاه شاهد انجام شد، التهاب با سه روش تزریق فرمالین، گزیلن یا اسید استیک به کف پا...
[ 34 ] - اثر ضددردی عصاره الکلی دانه گیاه بنگدانه در فازهای مختلف سیکل استروس موش صحرایی ماده
زمینه و هدف : نتایج تحقیقات مختلف در مقایسه حساسیت به تحریک دردناک حرارتی در دو جنس نر و ماده ، متفاوت و غیریکسان بوده است. در مراحل سیکل استروس نیز به دلیل هورمونی در آستانه درک درک تفاوت وجود دارد. با توجه به اثر ضددردی گیاه بنگدانه، این مطالعه به منظور تعیین اثر ضددردی عصاره الکلی دانه گیاه بنگدانه در فازهای مختلف سیکل استروس موش صحرایی ماده انجام شد. روش بررسی : در این مطالعه تجربی 92 سر...
[ 35 ] - اثر مصرف خوراکی حب مقل (Commiphora Mukul) بر میزان گلوکز و چربیهای سرم در موشهای صحرایی نر دیابتی
مقدمه: با توجه به وجود شواهد متعدد مبنی بر اثر کاهندهی لیپید حب مقل و آثار سودمند آن بر متابولیسم، در این بررسی اثرهای هیپوگلیسمیک و هیپولیپیدمیک این گیاه در مدل تجربی دیابت قندی مورد بررسی قرار گرفت. مواد و روشها: 56 موشهای صحرایی نر به طور تصادفی به چهار گروه شاهد، شاهد تیمار شده با حب مقل، دیابتی، و دیابتی درمان شده با مقل تقسیمبندی شدند. دو گروه تیمار شده با مقل، پودر گیاه مخلوط شده با ...
[ 36 ] - بررسی اثر مصرف مزمن مورفین بر فعالیت غده تیروئید در موشهای صحرایی نر
مقدمه: محور هیپوتالاموس ـ هیپوفیز در انواع وابستگیهای دارویی، به خصوص اعتیاد به مواد مخدر تحت تأثیر قرار میگیرد. با توجه به نقش کلیدی تیروئید در فعالیتهای حیاتی انسان و ارتباط مستقیم تیروئید با محور هیپوتالاموس ـ هیپوفیز، این مطالعه به بررسی اثر مزمن مورفین (وابستگی به مورفین) بر ترشحات تیروئید پرداخته است. شاید بتوان از نتایج این مطالعه برای درمان بیماران معتاد که علاوه بر تغییرات روانی با ...
[ 37 ] - Effects of Active Constituents of Crocus sativus L., Crocin on Streptozocin-Induced Model of Sporadic Alzheimer\'s Disease in Male Rats
Background: The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract in learning and memory processes has been proposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. Methods: Male adult Wistar rats (n = 90 and 260-...
[ 38 ] - The Role of Nitric Oxide and Prostaglandins in the Effect of Adenosine on Contractility, Heart Rate and Coronary Blood Flow in Guinea Pig Isolated Heart
It is a well-established fact that adenosine and its receptor subtypes (A 1 and A ) are involved in changes of contractility, heart rate and coronary blood flow (CBF) under different circumstances. This study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. For this purpose, Nitro-L-Arginine methyl ester (L-NAME), and indomethacin as inhibit...
[ 39 ] - Effect of stress due to food deprivation, social inequality and instability on brain
Introduction: Several reports show a relationship between health equity, and health status and longevity of individuals. In this study, effects of food deprivation, inequality and social instability were investigated on the formation of lipofuscin pigment in Balb/C mice by histopathological and biochemical methods. Methods: Thirty-six male mice were divided into 6 groups, then different kind...
[ 40 ] - Effects of dominant/subordinate social status on pain behavior and proinflammatory cytokines in the serum of mice
Introduction: The current investigations on Health Equity, primarily point to the harmful health consequences of being in a stressful social hierarchy. The repetitive nature of social conflicts seems to favor the induction of hyperalgesia or hypoalgesia both in rodents and humans, and it can also affect the immune system. In this study, the effects of changes in social status on pain percept...
[ 41 ] - بررسی اثر عصاره الکلی بذر گیاه تاتوره بر درد حاصل از آزمونهای فرمالین و صفحه داغ در موشهای صحرایی نر
گیاه تاتوره در کتابهای پزشکی کهن ایران و در سالهای اخیرا توسط محققان امروزی گونههای خاصی از این گیاه به عنوان گیاه ضد درد معرفی شده است. مشخص شده است که قسمتهای مختلف این گیاه بخصوص بذر آن حاوی آلکالوئیدهای مختلف میباشد. با توجه به تداخل سیستم اوپیوئیدی با مواد مختلف و از جمله مهمترین آنها آلکالوئیدها یا مواد قلیایی و نقش واضح سیستم اوپیایی در کنترل درد، تحقیق حاضر به مطالعه اثر عصاره الکلی ب...
[ 42 ] - The effect of electroconvulsive therapy on the levels of oxidative stress factors in the prefrontal cortex of depressed rats
Background and Objective: Electroconvulsive therapy (ECT) is one of the effective and less complicated methods for treatment of depression in cases of resistance to common treatments. Given the fundamental role of pre-frontal cortex on changing the mood of depression-related behaviors in depressed patients, the effects of electroconvulsive therapy on enzymatic activity of this cortex were taken...
[ 43 ] - Effects of Social Stresses on Immune Response in Female and Male Mice
Background: Social stress is a factor involved in the etiology of many diseases. Also, gender is another factor which predisposes individuals to certain disease. Results from animal and human studies suggest that socially-stressed men are more vulnerable to catching diseases compared to socially-stressed women. Materials and Methods: The role of chronic social stress and gender were examined in...
[ 44 ] - Behavioral function improvement of prefrontal cortex in treated depressed rats by ECT and ketamine
Background and Objective: Depression is one of the most prevalent mental disorders. Electroconvulsive Therapy (ECT) is one of the effective methods for treatment of depression. Regarding the stimulatory effect of glutaminergic system on the progression of depression, the effect of ketamine as one of the most important inhibitors of this system has been investigated on the effectiveness of ECT. ...
[ 45 ] - The effects of swimming exercise and Nepeta menthoides on depression and anxiety induced by reserpine
Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 g...
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