Modification with antibodies is a useful strategy for the delivery of nanoparticles to target cells. However, complexity required chemical modifications makes them time-consuming and low efficiency, orientation antibody challenging control. To develop simple, fast, effective, orientation-controllable technology, we employed staphylococcal protein A, which can bind Fc region antibodies, as tool ...

Pituitary neuroendocrine tumors (PitNET) are originating from adenohypophyseal cells. Although benign, PitNETs sometimes exhibit aggressive biological behavior that was the inspiration for change of old and traditional name "pituitary adenomas". Current standard in PitNET diagnostics, according to WHO criteria, is immunohistochemistry, with application antibodies adenohypophysis hormones transc...

Background: Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV these patients. Objectives: To investigate presence and clinical significance of antibodies levels plasma obtained brain tumors. Materials Methods: HCMV-specific IgG IgM antibody were determined 59 collected tumor incl...

Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we investigated the impact of antibody binding affinity on tumor targeting and penetration with affinity variants that recognize the same epitope. Specifically, we compared four derivatives of the C6.5 monoclonal antibody (mAb), which recogn...

Purpose: Overexpression of fibroblast growth factor receptor 2 (FGFR2) may be a causative factor of a number of human tumors, especially gastric tumors of the poorly differentiated type. We investigated whether monoclonal antibodies (mAbs) directed against FGFR2 can inhibit the growth of tumors in

background and objective: histopathological evaluation of granulosa cell tumors (gct) of the ovary may be confused morphologically with a wide variety of the tumors. immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. although it has been suggested that inhibin can be a sensitive marker for gct, it maybe had negative results in some cases.  in addition, cal...