using complement fixation technique, serial serum samples from 15 patients undergoing surgical removal of malignant tumors were assayed for the presence of tumors antibodies against the cellular fractions of both normal and carcinomatous tissue. antibody responses against tumor associated antigens were detected in four cases. in all cases antibody activity was directed only against the supernat...

The principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. This advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mAb). Radioactively-tagged antibodies which are applied in radioimmunotherapy (RIT), can target adjacen...

Abstract Background Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is limited. The combination of CAR-T with immune checkpoint inhibitors (CPIs), such as PD-1, PD-L1, and CTLA-4 antibodies, a promising strategy enhancing the antitumor cells. However, because most patients acquire resistanc...

the principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. this advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mab). radioactively-tagged antibodies which are applied in radioimmunotherapy (rit), can target adjacen...

background: tumors involving the hand skeleton are rare. however, a basic knowledge of hand tumors is necessary for every clinician. this is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. methods: this study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, imam khomeini hospital in tehr...

Widespread studies on tumor diagnosis has led to the development of techniques with greater sensitivity and improved specificity for detection of occult and small subclinical tumors. Tumor imaging by radiolabeling of tumor-specific antibodies (Immunoscintigraphy) or tissue specific biochemical agents (Receptor imaging) and especially physiologic imaging with positron emitters (PET), have ...

Abstract Bispecific antibodies (bsAbs) are some of the most promising biotherapeutics due to versatility provided by their structure and functional features. bsAbs simultaneously bind two antigens or epitopes on same antigen. Moreover, they capable directing immune effector cells cancer delivering various compounds (radionuclides, toxins, immunologic agents) target cells, thus offering a broad ...