Kimberley M Kendall MRCPsych, Elliott Rees, PhD, Valentina Escott-Price, PhD, Mark Einon, Rhys Thomas PhD, MRCP, Jonathan Hewitt PhD, MRCP, Michael C O’Donovan PhD, FRCPsych, Michael J Owen PhD, FRCPsych, James Walters PhD, MRCPsych, George Kirov* PhD, MRCPsych. 1 MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University School of Medicine, Division of Psychological Medicine and C...

The effects of voriconazole on the growth, ultrastructure, and leakage of cytoplasmic materials of Candida species were investigated. MIC data showed that voriconazole was more active than fluconazole. Exposure of yeast to voriconazole caused growth inhibition, cell wall thinning, and cell membrane degradation. Neither cell collapse nor release of cytoplasmic materials was observed in the treat...

Over the last decade, J. M. Robins has developed a set of tools for assessing, from observational data, the causal effects of a time-dependent treatment or exposure in the presence of time-dependent covariates that may be simultaneously confounders and intermediate variables. This report concerns a case study of the application of one these techniques, G-estimation using structural nested failu...

How is monetary policy transmitted through its impact on mortgage borrowings? How does this transmission mechanism depend on whether mortgages are fixed or floating rate? To address these questions, we add a model of financial institutions’ behaviour to a dynamic general equilibrium model in which some households face credit constraints. We use this model to analyse the real effects of inflatio...

Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of individuals, combining questionnaires with clinical, genetic, demographic, and imaging assessments; some of this data may be collected longitudinally. Genetic associations analysis of such datasets requires methods to pro...

Liver disease, especially Non-Alcoholic Fatty Liver Disease has reached high levels, and there is a need for non-invasive tests based on quantitative MRI to replace biopsy in order to better assess liver health. An automated quantitative liver segmentation approach is required to automate these tests and in this work we propose a fully convolutional framework with a novel objective function for...

The UK is unusual in providing universal free healthcare in which access to specialists is largely controlled by general practitioners with 24-hour responsibility, throughout the year, for a defined list of patients of all ages. It is generally considered that this gatekeeper function has contributed to the relatively low cost of the National Health Service, but major changes in the organisatio...

        This paper proposes a new forecasting model for investigating relationship between the price of crude oil, as an important energy source and GDP of the US, as the largest oil consumer, and the UK, as the oil producer. GMDH neural network and MLFF neural network approaches, which are both non-linear models, are employed to forecast GDP responses to the oil price changes. The resul...

In a referendum conducted in the United Kingdom (UK) on June 23, 2016, $51.6\%$ of the participants voted to leave the European Union (EU). The outcome of this referendum had major policy and financial impact for both UK and EU, and was seen as a surprise because the predictions consistently indicate that the ``Remain'''' would get a majority. In this paper, we investigate whether the outcome o...