1 Department of Pediatrics, University of Utah, Salt Lake City, UT, USA 2 Department of Neurology, University of Utah, Salt Lake City, UT, USA 3 Primary Children’s Medical Centre, Salt Lake City, UT, USA 4 Department of Radiology, University of Utah, Salt Lake City, UT, USA 5 Department of Psychology, University of Utah, Salt Lake City, UT, USA 6 Neuroscience Centre, Brigham Young University, P...

C. E. Harrison, R. J. DeBerardinis, A. K. Jindal, C. Yang, A. D. Sherry, and C. R. Malloy Advanced Imaging Research Center, UT Southwestern, Dallas, Texas, United States, Physics, UT Dallas, Richardson, Texas, United States, Pediatrics, UT Southwestern, Dallas, Texas, United States, McDermott Center for Human Growth and Development, UT Southwestern, Dallas, Texas, United States, Chemistry, UT D...

Dexamethasone treatment increases urea excretion and decreases urea permeability and urea transporter UT-A1 protein abundance in the inner medullary collecting duct (IMCD) of adrenalectomized rats. We examined the effect of dexamethasone treatment for 3 days on the abundance of several UT-A mRNA transcripts in rat renal medulla. By Northern blot analysis, a significant decrease in mRNA expressi...

Selective transporters account for rapid urea transport across plasma membranes of several cell types. UT-B1 urea transporter is widely distributed in rat and human tissues. Because mice exhibit high urea turnover and are the preferred species for gene engineering, we have delineated UT-B1 tissue expression in murine tissues. A cDNA was cloned from BALB/c mouse kidney, encoding a polypeptide th...

The UT-A1 urea transporter plays an important role in maintaining the hyperosmolar milieu of the inner medulla. Vasopressin increases urea permeability in rat terminal inner medullary collecting ducts (IMCDs) within 5-10 min. To elucidate the mechanism, IMCD suspensions were radiolabeled with [(32)P]orthophosphate. UT-A1 was immunoprecipitated and analyzed by autoradiogram and Western blot. Bot...

UT-B1 is the facilitated urea transporter of red blood cells (RBCs) and endothelial cells of descending vasa recta in the kidney. Immunoblotting with a polyclonal antibody against the C-ter sequence of rat UT-B1 revealed UT-B1 as both nonglycosylated (29 kDa) and N-glycosylated (47.5 and 33 kDa) proteins in RBC membranes, kidney medulla, brain, and bladder in rat. In testis, UT-B1 was expressed...

BACKGROUND Strengthening exercises for the scapular muscles are used in the treatment of scapulothoracic dysfunction related to shoulder injury. In view of the intermuscular and intramuscular imbalances often established in these patients, exercises promoting lower trapezius (LT), middle trapezius (MT), and serratus anterior (SA) activation with minimal activity in the upper trapezius (UT) are ...

Purpose To research the distribution and quantitative changes of UT-A1, UT-B1, and AQP5 in uremic skin tissue. Methods 34 cases of uremic patients (UP) and 11 controls were recruited. Immunohistochemistry, immunofluorescence, RT-PCR, and Western Blot were used to identify the proteins in sweat glands. Results AQP5, UT-A1, and UT-B1 were expressed and localized in human skin basal lines, ski...