this study investigated efficacy and side effects of morphine suppository for pain management after the first elective caesarean delivery in comparison to diclofenac suppository. one hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. exclusion criteria included drug sensitivity, fetal malformations or...

Paracetamol is commercially available in oral and rectal dosage forms for geriatric and pediatric patients. Limitation of oral drug delivery for pediatric patient is inconvenience to swallow the tablet, capsule and oral suspension; in such case suppositories are effective and often used. To achieve successful delivery of drug locally as well as systematically, rectal route has proved its potent...

AIM To determine the effects of hyoscine-N-butyl bromide (HBB) rectal suppository on labor progress in primigravid women. METHODS A randomized double-blind placebo-controlled clinical trial was carried out on 130 primigravid women admitted for spontaneous labor. The women were recruited based on the inclusion and exclusion criteria and randomized into the experimental (n=65) and control group...

 Though conception rates within 2 weeks of Eazi-BrEEd CIDR removal were lower for treated cows (27.7% vs 36.2% for controls, P < 0.083), overall pregnancy rates did not differ between treatment groups (P = 0.32). [Conception can be reduced by: 1) an older, unknown-aged egg being ovulated after an extended progesterone period; 2) vaginitis, so cleanliness and proper insertion technique are impo...

BACKGROUND The methods of evaluating endoscopic mucosal findings and the definition of mucosal healing in inflammatory bowel disease have not been standardized. AIM To examine a third-party central review of colonic mucosal evaluations. METHODS A double-blind, placebo-controlled, parallel-group trial was performed for 4weeks, which involved continuous administration of a 1-g mesalazine supp...

We prepared indomethacin (IM) sustained-release suppositories using sugar ester (SE) as an additive. The suppositories were prepared by the fusion method with IM, SE, and Witepsol H-15 (H-15) and their availabilities in vitro and in vivo were evaluated mainly by the drug release test and the absorption test in rabbits, respectively. The softening point of the suppositories increased with increa...

Background. Ulcerative proctitis (UP) is typically treated initially with oral 5-aminosalicylate ("5-ASA"), mesalamine suppository, or mesalamine enema ("UP Rx"). Little is known about their effectiveness in practice. Methods. Using a US health insurance database, we identified new-onset UP patients between January 1, 2005, and December 31, 2007, based on the following: (1) initiation of UP Rx;...

It has been well known that mesalazine can cause the interstitial lung disease, such as Bronchiolitis obliterans with organizing pneumonia (BOOP), Non-Specific Interstitial Pneumonia (NSIP), or eosinophilic pneumonia. 5-Aminosalicylic acid (5-ASA), mesalazine, and sulfasalazine are important drugs for treating inflammatory bowel disease. Topical products of these limited systemic absorption and...