نتایج جستجو برای: vaginal suppository
تعداد نتایج: 30513 فیلتر نتایج به سال:
The objective of this study was to develop vaginal suppository containing lactobacillus. Four kinds of vaginal suppositories containing Lactobacillus paracasei HL32 were formulated: 1) a conventional suppository with Witepsol H-15 as a base, 2) a conventional suppository with mixed polyethylene glycols (PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15 as a base and 4) a hollow-t...
Drug administration via mucosal membranes, including the vaginal, has the advantage of by passing the hepatogastrointestinal first pass metabolism associated with oral administration. Metronidazole suppositories were prepared using different suppository bases viz., water soluble bases ( PEGs and gelatin ) emulsion and fatty bases. The physicochemical properties of most of the prepared MTZ suppo...
OBJECTIVES We performed a phase I trial to assess the safety and tolerance of a Lactobacillus vaginal suppository for prevention of recurrent UTI. METHODS Premenopausal women with a history of recurrent UTI were randomized to use L. crispatus CTV-05 or placebo vaginal suppositories daily for five days. RESULTS 30 women were randomized (15 to L. crispatus CTV-05). No severe adverse events oc...
Introduction: Vaginal dryness is a common symptom after menopause and reduction of estrogen levels. Prescription of the drug can temporarily be effective but it will not be possible for most of the women to take them for a prolonged period of time. Therefore, as an alternative to estrogen replacement, this study was conducted to determine the effect of vitamin D on vaginal dryness in menopause ...
Introduction: Adequate levels of progesterone and efficient uteroplacental circulatory system are considered as two important factors in maintaining normal pregnancy. Conspicuously, increased vascular resistance in the uterine artery can lead to severe complications including threatened abortion by an impairment to the embryo’s blood supply. This study was conducted to determine whether vaginal...
OBJECTIVE The pharmacokinetics of a 100 mg vaginal progesterone suppository was evaluated on days 1 and 7 and a 200 mg suppository on day 14. All the volunteers were given oral 17 beta-estradiol during the study. STUDY DESIGN Ten postmenopausal women volunteered for this study. Progesterone was given as a vaginal suppository. Peripheral venous samples were obtained at appropriate intervals an...
AIMS Miconazole is a synthetic imidazole antifungal that has a broad spectrum of activity against Candida albicans and non-albicans Candida species. The aim of this study was to evaluate the efficacy and safety of miconazole nitrate vaginal suppository and oral fluconazole in treating severe vulvovaginal candidiasis (SVVC). METHODS In this prospective, randomized case control study, 577 cases...
background & aim: menopause is one of the most critical stages in a woman’s life. special attention needs to be paid to the quality of life of menopausal women. symptoms of genitourinary atrophy can affect women’s comfort and quality of life. the aim of this study was to compare two treatment methods of vitamin e suppository and conjugated estrogens vaginal cream on the quality of life of meno...
Background & Aim: Bacterial vaginosis is characterized by an imbalance in vaginal natural discharges due to an overgrowth of anaerobic bacteria as well as a concomitant decrease in the number of lactobacilli and increase in vaginal PH to more than 4.5. Bacterial vaginosis increases the risk of pelvic inflamatory disease, postoperative infection following hysterectomy, cervix abnormal cytology a...
abstract background: most of the women suffer from vaginal atrophy and dryness, and therefore, efficient and safe treatment is needed to improve vaginal lubrication. vitamin d has several important functions which may be effective in proliferation and repair of the epithelial tissue. this study aimed to evaluate the effect of vitamin d vaginal suppositories on maturation index, ph, and dryness ...
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