A microfabricated electroporator (MFE) for the irreversible electroporation (IRE) of tissues has been developed by miniaturizing a clinical electroporator with a two-needle array while keeping the same electric field strength distribution. Since IRE was brought to special attention as one of the local tissue ablation techniques to treat tumors, many preclinical studies have been conducted to in...

In this study we used incorporation of the DNA synthesis marker 5-bromo-2’-deoxyuridine or BrdU to visualize cell proliferation in the visual system of the adult mouse as a response to monocular enucleation. We detected new BrdU-labeled cells in different subcortical retinal target regions and we established a specific time frame in which this cell proliferation occurred. By performing immunofl...

Brain and spinal cord autopsies aimed at neuropathological diagnosis of the causes of dementia and motor abnormalities are of increasing importance. Neuropathological brain examination is often the only diagnostic modality capable of definitive diagnosis of a neurodegenerative disease and thus serves as invaluable feedback for clinicians and biochemical and imaging diagnostics. The brain and sp...

0031-9007= We show that matter effects change the ! oscillation probability by as much as 70% for certain ranges of energies and path lengths. Consequently, the ! survival probability also undergoes large changes. A proper understanding of survival rates must consider matter effects in P as well as P e. We comment on (a) how these matter effects may be observed and the sign of 31 determined in ...

Model a network as an edge-weighted graph, where the (unknown) weight we of edge e indicates the frequency of observed interactions, and over time t we observe a Poisson(twe) number of interactions across edges e. How should we estimate some given statistic of the underlying network? This leads to wide-ranging and challenging problems, on which this article makes only partial progress.

The growth plates of the femoral head of Japanese white rabbits aged 5, 10, 15 and 20 weeks were stained for apoptotic and proliferating chondrocytes using the TUNEL and PCNA antibody staining techniques. Both TUNEL- and PCNA-positive chondrocytes were detected in all of the specimens. The positive ratios of both stainings were calculated for the whole plate and for the resting, proliferating a...