To clarify the pharmacological characteristics of Nalpha-amidino-Tyr-D-Arg-Phe-betaAla-OH (ADAB) and Nalpha-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB), mu1-opioid receptor-selective [D-Arg2]dermorphin tetrapeptide analogs, the plasma pharmacokinetics, and the in vivo blood-brain barrier (BBB) transport of these peptides were quantitatively evaluated. The mechanism responsible for the BBB transp...

Background In the period 2003-2008, the regulatory authorities issued several warnings restricting the use of selective serotonin re-uptake inhibitors (SSRIs) in paediatrics, in reaction to safety concerns regarding the risk of suicidality. In this study, the SSRIs and suicidality controversy serves as a template to analyse the long-term publication trends regarding the benefit/risk profile of ...

Writing journal articles is one of the final assignments for students Department Al-Qur'an and Tafsir (IAT), Faculty Ushuluddin, Adab, Da'wah (FUAD) IAIN Tulungagung. Journal are clearly not as many theses, however, it does mean that when choose assignments, they can do easily quickly. Many actually experience difficulties so process writing takes a long time. Based on its problems, this articl...

Research article writing has received a great deal of attention from ESP researchers. Analyses of the general structure of Introduction-Method-Results-Discussion (IMRD) articles, as well as detailed analyses of individual sections, including introductions, results, and discussions sections, have dominated the ESP literature, especially following Swales' pioneering work on introductions in the e...

OBJECTIVE To investigate the replication validity of biomedical association studies covered by newspapers. METHODS We used a database of 4723 primary studies included in 306 meta-analysis articles. These studies associated a risk factor with a disease in three biomedical domains, psychiatry, neurology and four somatic diseases. They were classified into a lifestyle category (e.g. smoking) and...

PURPOSE To determine the volume and focus of articles on four chronic diseases in newspapers targeting First Nations, Métis, and Inuit in Canada. METHODS From a sampling frame of 31 Aboriginal newspapers published in English from 1996-2000, 14 newspapers were randomly selected allowing for national and regional representation. Newspaper archives were searched at the National Library of Canada...

(WHO) issued a global alert regarding severe acute respiratory syndrome (SARS) in Vietnam, Hong Kong, and China's Guangdong Province. Three days later, for the first time in its history , WHO recommended postponing nonessential travel to the affected areas and screening airline passengers (1). These initiatives, together with the awareness of the modes transmission of the coronavirus associated...