Introduction: The diagnosis of chronic lymphocytic leukemia/ small lymphoma (CLL/SLL), which also includes atypical forms, can be very difficult. aim this study is to compare immunohistochemical (IHC) and flow cytometric (FC) immunophenotyping methods in the CLL/SLL, most common mature B-cell leukemia/lymphoma adults, bone marrow biopsy. In these two methods, it determine minimum panels that di...

Among various treatments, plants play a crucial role in cancer chemotherapy. Base on literature data, different species of the thymeleaeceae family have been found to be good sources for anticancer agents. Therefore, our laboratory has initiated a research project on evaluating the anticancer properties of the Iranian medical plant, Daphne mucronata (Thymeleaeceae). Gnidilatimonoein is a new di...

An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these events which disrupts regulation of cell cycle and subsequently, results in cancer progression. In this study, we surveyed the repressive impact of mu...

Evaluation the Effect of Chemotherapy Drugs and Thiosemicarbazone Complexes on Expression URHC CASC15 LncRNAs in Acute Lymphoblastic Leukemia Cell Line

Recently, Gentile et a l l reported what they believe to be a new disease, ie, CD3+, CD56' aggressive variant of large granular lymphocyte (LGL) leukemia. At presentation or during the course of the disease, all 3 patients were reported to have an absolute lymphocytosis, a moderate degree of thrombocytopenia, and massive splenomegaly, Splenectomy specimens in all 3 cases showed preferential inv...

Recently, Gentile et a l l reported what they believe to be a new disease, ie, CD3+, CD56' aggressive variant of large granular lymphocyte (LGL) leukemia. At presentation or during the course of the disease, all 3 patients were reported to have an absolute lymphocytosis, a moderate degree of thrombocytopenia, and massive splenomegaly, Splenectomy specimens in all 3 cases showed preferential inv...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...

introduction: the majority of leukemia patients are acute leukemia patients, so that about 70.8% lymphoblastic leukemia were acute lymphoblastic leukemia (all) patients and 66.4 % of myeloid leukemia patients were acute myeloid leukemia (aml) in tehran metropolitan. during the last two decades, intensification of therapy by the use of high-dose cytarabine allogeneic stem cell transplantation in...