Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

Recently, evidence was reported for the belief that a carcinogenic agent, †̃20-methyleholanthrene, could be secreted into the milk of a lactating ani mal and thereby gain entrance into the bodies of the offspring to cause an abnormally high mci dence of neoplasms (1). Further positive evidence for this mode of excretion of methyleholanthrene has now been obtained by means of ultraviolet ab sor...

The 0-24-h urinary metabolic profile of cyclophosphamide was inves tigated in a series of 14 patients with various malignancies receiving combination chemotherapy including i.v. cyclophosphamide. This was accomplished using combined thin-layer chromatography-photographydensitometry, which can quantitate cyclophosphamide and its four prin cipal urinary metabolites (4-ketocyclophosphamide, nor-ni...

â  â  â  â â â  methods of speakers' effects on the audience â  â nasrollah shameli * â  fariba hosayni ** â â â  abstract â  this article is focused on four issues. the first issue is related to the speaker's external appearance including the beauty of face, the power of his voice, moves and signals by hand, the stick and eyebrow as well as the height. such characteristics could have...

â â â â â â â â â  the inner meaning of the holy quran â  â  hamid ahmadian * â â â abstractâ  the inner self (‘batin’) in the quran is set in opposition to the outer appearance (‘zaher’). ‘batin’ may have a variety of interpretations the most well-known of which are intended to be documented in this paper. different interpretations of ‘batin’ based on different opinions are as ...

to be useful in practice (Felkenes, 1980). When ethical decision-making and the organization have been studied empirically, researchers found that those who rely on organizational rules deliberate somewhat differently on ethical issues than do those practitioners who use ethical principles to guide their decision-making (Kugelman-Jaffee, 1990). Thus, the challenge for hospital based social wo...

We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...