نتایج جستجو برای: تست h1
تعداد نتایج: 29775 فیلتر نتایج به سال:
موضوع پایان نامه: سنتز مشتقات 2و3-دی هیدروکینازولین- (h1)4-اون دارای استخلاف در موقعیت 2 در مجاورت و عدم حضور کاتالیزگر پاراتولوئن سولفونیک اسید و شناسایی مواد تشکیل دهنده و بررسی فعالیت بیولوژیکی اسانس گیاه fumaria vaillantii loisel (شاتره تال) استان کردستان در ایران. اهداف: سنتز مشتقات 2و3-دی هیدروکینازولین- (h1)4-اون دارای استخلاف در موقعیت 2 و شناسایی مواد تشکیل دهنده و بررسی فعالیت بیولوژ...
3،2-دی هیدروکینازولین-4 (1h)- اون هابدلیل داشتن خواص بیولوژیکی و دارویی، ترکیبات مهمی بشمار می آیند. روش های سنتزی سودمندی برای تهیه این ترکیبات گزارش شدهاست که شامل واکنش تراکمی سه جزئی بین ایزاتوئیک انیدرید، آمین نوع اول و آلدهیدهای آروماتیک یا آلیفاتیک و همچنین واکنش تراکمی بین2-آمینوبنزآمید با آلدهیدهای آروماتیک یا آلیفاتیک می باشد. بسیاری از ترکیبات دارویی در اثر اکسایش بوسیله اکسایش حرار...
An additional hydrolysis site recognized by thrombin on histone H1 molecules was found. Snakes venom proteases from Agkistrodon rhodostoma, Bothrops marajoensis and Bothrops moojeni were further used for the analysis of H1 histones. The presence of the main cleavage site on H1 histone molecules has been established. This site is localized on main N-terminal thrombin peptide. The main venom prot...
In Tetrahymena cells, phosphorylation of linker histone H1 regulates transcription of specific genes. Phosphorylation acts by creating a localized negative charge patch and phenocopies the loss of H1 from chromatin, suggesting that it affects transcription by regulating the dissociation of H1 from chromatin. To test this hypothesis, we used FRAP of GFP-tagged H1 to analyze the effects of mutati...
We recently demonstrated that linker histone H1, which is thought to have a fundamental role in higher-order chromatin structure, becomes transiently dephosphorylated after ionizing radiation (IR) in a mutated ataxia telangiectasia (ATM) dependent manner. To establish whether H1 dephosphorylation was a component of a damage-response pathway that included dephosphorylation of other histones, we ...
Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress caused by blood flow. The mechanism that couples shear stress to migration has not been fully elucidated. We found that mice lacking GEF-H1 (GEF-H1-/-), a RhoA-specific guanine nucleotide exchange factor (GEF), displayed limited migration and recruitment of neutrophils into inflamed tissues. GEF-H1-/- leukoc...
Epigenetics plays critical roles in controlling stem cell self-renewal and differentiation. Histone H1 is one of the most critical chromatin regulators, but its role in adult stem cell regulation remains unclear. Here we report that H1 is intrinsically required in the regulation of germline stem cells (GSCs) in the Drosophila ovary. The loss of H1 from GSCs causes their premature differentiatio...
High mobility group 1 protein (HMG1) has traditionally been considered a structural component of chromatin, possibly similar in function to histone H1. In fact, at the onset of Xenopus and Drosophila development, HMG1 appears to substitute for histone H1: HMG1 is abundant when histone H1 is absent after the midblastula transition histone H1 largely replaces HMG1. We show that in early mouse emb...
We use the abbreviation x1:k for x1, . . . , xk, o1:k for o1, . . . ok, h1:k for h1, . . . , hk. The sequence of DDO times up to observation time tk is denoted τ (1, k) = {ti : hi = 1, i = 1, . . . , k}. Forward functions are defined as αtk(u) = P [o1:k, τ (1, k),h1:k, Xk = u] and backward functions as βtk(u) = P[ok+1:n, τ (k + 1, n),hk+1:n|Xk = u]. The forward function is initialized with αt1(...
H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the preventi...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید