Long non-coding RNAs (lncRNAs) associated with various cancers, including colorectal cancer (CRC), could be collected from body fluids easily. Our aims were to determine the expression level of HOTTIP lncRNA in plasma samples of healthy individuals and CRC patients as well as their relationship with clinico-pathological characteristics of patients. First, total RNA was extracted from the plasma...

Additional on-chip transistors as well as more aggressive processors have led the way for an ever expanding memory hierarchy. Multi-core architectures often employ the use of a shared L3 cache to reduce accesses to off chip memory. Such memory structures often incur long latency (as much as 30 cycles in our framework) and are configured to retain sets as large as 16 way. A baseline replacement ...

We propose a recursive formula for computing the remainder of a Euclidean division of polynomials (with binary coefficients), which operates in parallel on w bits at a time and takes t new incoming bits at each stage. We use this formula to design a fast parallel Cyclic Redundancy Check (CRC) system which is a look-ahead scheme that trades in arbitrary depth (processing time per cycle) and thro...

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own ...

Background: Most cancer studies focus on exploring non-invasive biomarkers for cancer detection. In the present study, we sought to investigate the expression level of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal cancer (CRC) and 40 healthy controls. Methods: Quantitative real-time RT-PCR was applied to determine the relativ...

Introduction Colorectal carcinoma (CRC) is one of the most common cancers that involve human body. Young-onset CRC (YO-CRC) or early-onset (EO-CRC) defined as develops before age 50 years, opposed to diagnosed after 50, referred late-onset (LO-CRC). EO-CRC sparsely studied in our population. Therefore, this study, we evaluated clinicopathological parameters and biomarker profile compared them w...