Genome-wide association studies have identified strong associations between the risk of developing Parkinson's disease (PD) and polymorphisms in the genes encoding α-synuclein and the microtubule-associated protein tau. However, the contribution of tau and its phosphorylated form (p-tau) to α-synuclein-induced pathology and neuronal dysfunction remains controversial. We have assessed the effect...

BACKGROUND Cognitive impairment strikingly reduces the quality of life of Parkinson's disease (PD) patients. Studies find that pathological proteins, neuroinflammatory factors and free radicals may involve in the pathogenesis of cognitive impairment of PD, however, results are inconclusive. METHODS We recruited 62 PD patients and 31 healthy controls. PD patients were identified with cognitive...

OBJECTIVE This study characterizes the expression of tau (p-tau) and α-synuclein (α-syn) by immunohistochemistry in the skin of three different populations: healthy control (HC), Parkinson disease (PD), and progressive supranuclear paralysis (PSP) subjects, with the purpose of finding a biomarker that could differentiate between subjects with PD and PSP. MATERIAL AND METHODS We evaluated the ...

INTRODUCTION A decreased cerebrospinal fluid (CSF) p-Tau181 to total tau ratio (p/t-tau) is a biomarker for frontotemporal lobar degeneration with TDP43 inclusions (FTLD-TDP) and for amyotrophic lateral sclerosis (ALS). CSF light chain neurofilaments (NfL) are increased in ALS. We examined whether CSF p/t-tau and NfL are related to ALS status in FTLD-TDP. METHODS We compared CSF p/t-tau and N...

We study the oscillatory and nonoscillatory behavior of solutions a class forced impulsive nonlinear neutral differential systems form $$ \left\{\begin{array}{c}{\left(r(t){\left(y(t)+p(t)y\left(t-\tau \right)\right)}^{\prime}\right)}^{\prime }+q(t)G\left(y\left(t-\sigma \right)\right)=f(t),\kern1.75em t\ne {\tau}_k,\kern0.75em k\ \epsilon\ \mathbb{N},\\ {}\Delta \left(r\left({\tau}_k\right){\l...

A Lorentzian manifold endowed with a time function, $\tau$, can be converted into metric space using the null distance, $\hat{d}_\tau$, defined by Sormani and Vega. We show that if function is proper regular cosmological as studied Andersson, Galloway Howard, also Wald Yip, or if, more generally, it satisfies anti-Lipschitz condition of Chru\'sciel, Grant Minguzzi, then causal structure encoded...

Aims: In this study, we aimed to evaluate the relationship between sleep disorder and serum tau protein levels in children with cerebral palsy.
 Methods: The sample was selected among aged 6-10 years who applied our physical medicine rehabilitation outpatient clinic. order quality, Pittsburgh Sleep Quality Index (PSQI) questionnaire recorded by asking parents of all participants. Children ...

Background While cutoffs for abnormal levels of the cerebrospinal fluid (CSF) biomarkers amyloid β 1-42 (Aβ 1-42), total tau (t-tau), phosphorylated (p-tau), and ratios t-tau/Aβ p-tau/Aβ 1-42, have been established in Alzheimer’s disease (AD), biologically relevant not studied extensively Parkinson’s (PD). We aim to assess suitability diagnostic accuracy AD-derived CSF biomarker PD population. ...

The microtubule assembly-promoting activity of different pools of tau protein isolated from Alzheimer disease (AD) and control brains and the effect of dephosphorylation on this activity were studied. Tau isolated from a 2.5% perchloric extract of AD brain had almost the same activity as that obtained from control brain, and this activity did not change significantly on dephosphorylation. Abnor...