Background: Many methods under the umbrella of inter-rater agreement (IRA) have been proposed to evaluate how well two or more medical experts agree on a set outcomes. The objective this work was assess key IRA statistics in context multiple raters with binary Methods: We simulated responses several (2–5) 20, 50, 300, and 500 observations. For each combination observations, we estimated expecte...

Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the second messenger cyclic AMP (cAMP) in response to various stimuli. Reduction of AC activity has well documented benefits, including benefits for heart disease and pain. These roles have inspired development of isoform-selective AC inhibitors, a lack of which currently limits exploration of functions and/or treatme...

In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-pro...

In this paper we give a characterization of both Boolean and arithmetic circuit classes of logarithmic depth in the vein of descriptive complexity theory, i.e., the Boolean classes NC1, SAC1 and AC1 as well as their arithmetic counterparts #NC1, #SAC1 and #AC1. We build on Immerman’s characterization of constant-depth polynomial-size circuits by formulae of first-order logic, i.e., AC0 = FO, an...

Lithium, valproate and carbamazepine decrease brain cAMP. Adenylyl-cyclase (AC), which synthesizes cAMP has nine membrane-bound isoforms (AC1-AC9). In this study we used COS7 cells transfected with cDNA of each of the isoforms to study the effect of a therapeutic concentration of each of lithium, carbamazepine and valproate on ACs activity. AC5 was the most inhibitable isoform by lithium and ca...

The C1 promoter expressing the AC1 gene, and V1 promoter expressing the AV1 gene are located in opposite orientations in the large intergenic region of the Cotton leaf curl Burewala virus (CLCuBuV) genome. Agro-infiltration was used to transiently express putative promoter constructs in Nicotiana tabacum and Gossypium hirsutum leaves, which was monitored by a GUS reporter gene, and revealed tha...

In this study, an integrated structure of the air separation unit, natural gas liquids recovery equipped with nitrogen removal unit is developed. In this regard, advanced exergy and exergoeconomic analyses are used to examine the irreversibility, possible improvements and the cost of the inefficiencies of the process. The exergy analysis presents information on the origin of the irreversibility...