نتایج جستجو برای: کدون v57i aurka
تعداد نتایج: 1108 فیلتر نتایج به سال:
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identification of a common transcriptional signature across mutant KRAS cancers of distinct tissue origin that...
The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates five networks of kinases that regulate the switch to polyploidy. Moreover, we fi...
Most of the cancers that arise in the mucosa of the upper aerodigestive tract, including the oral cavity, pharynx, and larynx, are squamous cell carcinomas. To date, although there are no primary mutations that have been discovered to cause these cancers, aberrant expression of a variety of molecules characterizes head and neck squamous cell carcinoma (HNSCC). Most of the studies have compared ...
High-grade serous ovarian carcinoma (HGSC), the most common and aggressive histological type of cancer, remains leading cause cancer-related deaths among females. It is important to develop novel drugs improve therapeutic outcomes HGSC patients, thereby reducing their mortality. Symmetry one properties biological network, which determines stability a system. As aberrant gene expression critical...
The clinical prognosis of patients with glioma is determined by tumor grades, but tumors of different subtypes with equal malignancy grade usually have different prognosis that is largely determined by genetic abnormalities. Oligodendrogliomas (ODs) are the second most common type of gliomas. In this study, integrative analyses found that distribution of TCGA transcriptomic subtypes was associa...
PURPOSE The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor. EXPERIMENTAL DESIGN Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and correlated with survival time of the patient. Microarray analysis was conducted on MiaPaCa2 cells subjected to metabolic stress in Nupr1-silenced conditions. DN...
Gastric cancer is one of the most common cancers and responds poorly to current chemotherapy. Alisertib (ALS) is a second-generation, orally bioavailable, highly selective small-molecule inhibitor of the serine/threonine protein kinase Aurora kinase A (AURKA). ALS has been shown to have potent anticancer effects in preclinical and clinical studies, but its role in gastric cancer treatment is un...
مقدمه: سندرم تخمدان پلی‌کیستیک (PCOS) یک بیماری شایع و پیچیده در زنان است. اگرچه نقش عوامل ژنتیکی در PCOS به شدت مطرح است، ولی ژن‌هایی که در سبب شناسی یا اتیولوژی این سندرم درگیر است، تاکنون به طور کامل بررسی و گزارش نشده است. مطالعه حاضر با هدف بررسی ارتباط پلی مرفیسم یا چند شکلی دو کدون 164 و 27 ژن گیرنده بتادو آدرنرژیک در PCO انجام شد. روش کار: این مطالعه مقطعی در سال 93-1392 بر روی 100 بیما...
مطالعات زیادی در زمینه اریبی کدون در موجودات مختلف صورت گرفته است، اما هنوز بحث های زیادی در مورد آن وجود دارد. در این مطالعه، با دید بیوانفورماتیکی به بررسی این پدیده در چرخه های متابولیکی مهم در گاو پرداخته شده است. اریبی کدون و پارامترهای مهمی مانند شاخص سازگاری کدون، میزان gc و غیره و نیز الگوهای کدونی بکار رفته در چرخه ها با نوشتن برنامه ای به زبان r مورد بررسی قرار گرفتند. با توجه به پیش ...
Adolfsson L. (Sweden) Aik S. (Malaysia) Begue T. C. (France) Birkholtz F. F. (South Africa) Blokhuis T. J. (Netherlands) Blonna D. (Italy) Bose D. (United Kingdom) Burkhart K. (Germany) Calder P. (United Kingdom) den Hartog D. (Netherlands) Donnan L. T. (Australia) Eilertsen L. (Norway) Ekholm C. (Sweden) Eygendaal D. (Netherlands) Faymonville C. (Germany) Fernandez F. (Germany) Ferreira N. (So...
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