Selective deficiency of immunoglobulin A (IgA) is the most frequent primary hypogammaglobulinemia. As some IgA-deficient patients have IgA antibodies in their plasma which may cause anaphylactic reactions, blood centers usually maintain a list of IgA-deficient blood donors to prepare compatible blood components. In this study we determined the incidence of selective IgA deficiency (SIgAD) in no...

Ankylosing spondylitis (AS) is associated with IgA nephropathy. To study the pathogenetic mechanism of this association the presence of haematuria and circulating IgA containing immune complexes (IgA ICs) in 70 patients with AS was determined. In this retrospective study haematuria was present in 15 patients and 25 patients had IgA ICs. Circulating IgA ICs were shown in 9/15 (60%) of the patien...

This study was performed in 77 HIV1 seropositive adult patients to characterise the IgA hyperglobulinaemia seen in the serum during the course of HIV infection. It was shown that both IgA1 and IgA2 subclass concentrations were simultaneously increased but the IgA1 increase was predominant. Secretory IgA (SIgA) concentration was significantly increased and IgA activity to gliadin, bovine serum a...

This paper explores the flexile flow lines where setup times are sequence- dependent. The optimization criterion is the minimization of total weighted completion time. We propose an iterated greedy algorithm (IGA) to tackle the problem. An experimental evaluation is conducted to evaluate the proposed algorithm and, then, the obtained results of IGA are compared against those of some other exist...

Abstract Despite ongoing efforts to characterize the host response toward SARS-CoV-2, a major gap in our knowledge still exists regarding magnitude and duration of humoral response. Analysis antibody mild versus moderate/severe patients, using new developed quantitative electrochemiluminescent assay for detecting IgM/IgA/IgG antibodies SARS-CoV-2 antigens, revealed rapid onset IgG/IgA antibodie...

Siegler, D. I. M. and Citron, K. M. (1974). Thorax, 29, 313-316. Serum and parotid salivary IgA in chronic bronchitis and asthma. It has been suggested that immunoglobulin A (IgA) deficiency may be an important predisposing factor to infection in chronic bronchitis and that this occurs more often in extrinsic asthmatics than in normal subjects. These claims have been investigated by measurement...

Immunoglobulin A (IgA) was demonstrated in equine serum and secretions. This immunoglobulin had a molecular weight extending from 150,000 to 700,000 and reacted with specific antihuman alpha-chain antiserum. Antigenic determinants specific for secretory IgA were demonstrated and found to be absent on serum IgA. Antigen binding activity was detected in IgA from tears. Purified IgA was antigenica...