Background & AimsTreatments are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can reduce symptoms nausea and vomiting. We investigated the safety efficacy tradipitant, an antagonist NK1R, in patients with idiopathic or diabetic gastroparesis.MethodsWe performed a double-blind trial 152 adults gastroparesis at 47 sites United States from November 2016 t...

We study the dust depletion pattern in eight well separated components of the zabs = 1.973, log N(H i) = 20.83, damped Lyman-α system toward Q 0013−004, four of which have detectable H2 absorption. The apparent correlation between the abundance ratios [Fe/S] and [Si/S] in the components indicates that the abundance pattern is indeed due to dust-depletion. In particular, we find evidence for dep...

Two new isocoumarin derivatives, including a new 5-hydroxy-8-methyl-2H, 6H-pyrano[3,4-g]chromen-2,6-dione (1) and 6,8-dihydroxy-3,7-dimethylisocoumarin (2b), a new chevalone derivative, named chevalone E (3), and a new natural product pyripyropene S (6) were isolated together with 6, 8-dihydroxy-3-methylisocoumarin (2a), reticulol (2c), p-hydroxybenzaldehyde, chevalone B, chevalone C, S14-95 (4...

BACKGROUND Previous work has demonstrated that vitamin E succinate (VES), an ester analogue of vitamin E, inhibits the growth of melanoma in vitro. However, there is no information about the effect of VES on melanoma in vivo. We investigated the effect of VES on melanoma in vitro and in vivo. METHODS The effect of VES on the proliferation and apoptosis of the B16F10 murine melanoma cell line ...

Background: The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of innate immunity and have been gradually recognized as a critical mediator in various autoimmune diseases; also, their role in chronic kidney disease and acute kidney injury has b...

0013-7944/$ see front matter 2012 Elsevier Ltd doi:10.1016/j.engfracmech.2012.02.005 ⇑ Corresponding author. E-mail addresses: [email protected] (S.G. Kelle Embrittlement of ductile structural members, whether under the presence of static or cyclic loading, can occur when surrounded by a corrosive environment. Several examples of catastrophic failures due to a form of environmentally assiste...

Plasmodium falciparum malaria remains a major cause of morbidity and mortality in many tropical countries, especially those in sub-Saharan Africa. Human genetic control of malaria infection is poorly understood; in particular, genes controlling P. falciparum blood infection levels remain to be identified. We recently evidenced the existence of complex genetic factors controlling blood infection...