Background: Endometriosis is a gynecological disease associated with severe pelvic pain and infertility. Immunological changes that occur in patients with endometriosis include reduced natural killer cell and T-lymphocyte cytotoxicity in the peritoneal fluid, and an elevated number of activated macrophages. MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation an...

background : cytokines produced by different subsets of t cells are the key mediators to adjust the quality of immune responses. despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. in this study we attempt to evaluate the expression profile of several cytokines from the t helper 1 and 2 subsets in blood cells from patients ...

background: the omega-3 (ω-3) fatty acid eicosapentaenoic acid (epa) is currently used in the clinic as a nutritional supplement to improve infertility, particularly in women with polycystic ovarian syndrome (pcos).objective: the present study was designed to investigate the effect of epa on insulin-like growth factor 1 (igf-1) and cyclooxygenase 2 (cox-2) gene expression in primary cultured gr...

Background: Ectopic pregnancy (EP) is a complication of conception in which the embryo implants outside of uterine cavity. The increasing incidence of serious maternal morbidity resulting from EP has prompted the search for biomarkers to aid in early diagnosis and take advantage of conservative treatments. One of the effective biomarkers in EP is vascular endothelial growth factor (VEGF). VEGF ...

Background & Objective: Human epidermal growth factor receptor 2 (HER-2) exhibits a vast range of expression in esophageal squamous...

background: glucose uptake by muscles and fat cells is carried out by the glut4 system. isoforms of the snap23, syntaxin-4 and vamp-2 play an important role in regulating glut-4 trafficking and fusion in adipocytes. the changes of snare proteins levels and thus impaired glut-4 displacement can be one of the etiological causes of type 2 diabetes. due to changes in the expression of these protein...

Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

Metastasis to lymph nodes and distant organs is the main challenge in the treatment of papillary thyroid cancer. In the current investigation, we aimed to evaluate the synergistic effects of celecoxib (CX) and sodium valproate (VPA) against cell survival, invasiveness properties, and expression of metalloproteinase-2 and -9 (MMP-2 and MMP-9) in  papillary thyroid cancer cell line, BCPAP cells. ...

Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...