Mehdi Rezayat

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.

[ 1 ] - The Effect of Pentoxifylline on bcl-2 Gene Expression Changes in Hippocampus after Ischemia-Reperfusion in Wistar Rats by a Quatitative RT-PCR Method

Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

[ 2 ] - Sub-chronic Dermal Toxicity of Silver Nanoparticles in Guinea Pig: Special Emphasis to Heart, Bone and Kidney Toxicities

Silver nanoparticles (Ag NPs) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. Present study compares the tissue levels of Ag NPs in different organs of Guiana Pigs quantitatively after dermal application and analysis the morphological changes and pathological abnormalities on the basis of the Ag NPs tissue levels. Before toxicological assessments,the...

[ 3 ] - The Nanocurcumin Reduces Appetite in Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): A Double-Blind Randomized Placebo-Controlled Clinical Trial

Objective(s): Various beneficial effects of curcumin have been seen specially as anti-inflammator and antioxidant agent. However, until now no human studies have been done on curcumin’s role in control of appetite. So, the present study was done to determine the effect of nanocurcumin on appetite in obese Non-Alcoholic Fatty Liver Disease (NAFLD) patients.Materials and Methods: This study was d...

[ 4 ] - Electrospun polymeric nanofibers for transdermal drug delivery

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

[ 5 ] - Dermal toxicity of Colloidal Nanosilver in Albino Rabbit: A New Approach to Physicochemical Properties

Objective(s): Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs), therefore regulatory health risk assessment has become necessary for the saf...

[ 6 ] - The Effect of Pentoxifylline on bcl-2 Gene Expression Changes in Hippocampus after Ischemia-Reperfusion in Wistar Rats by a Quatitative RT-PCR Method

[ 7 ] - Sub-chronic Dermal Toxicity of Silver Nanoparticles in Guinea Pig: Special Emphasis to Heart, Bone and Kidney Toxicities

[ 8 ] - W6: Self‐Assembling Peptide Nanofiber Containing Biologic Motif Induces Neural Differentiation, Tubulin Polymerization and Neurogenesis In‐Vitro, Ex‐Vivo and In‐Vivo Studies

لطفاً به چکیده انگلیسی مراجعه شود.

[ 9 ] - P51: Thermogel Nanofiber Induces Human Endometrial-Derived Stromal Cells to Neural Differentiation and Improves Motor Dysfunction Following Spinal Cord Injury

لطفاً به چکیده انگلیسی مراجعه شود.

[ 10 ] - بررسی اثر بهبود حرکتی نانوفیبر خود سامانده در مدل ضایعۀ نخاعی در موش صحرایی

مقدمه: صدمۀ نخاعی یک وضعیت ناتوان‌کنندۀ خطرناک است که می‌تواند منجر به فلج ‌شدن گردد. به‌ علت اثرات سودمند هیدروژل در مقایسه با داربست‌های از پیش ساخته شده، در این مطالعه یک زیست ماده‌ بر پایۀ هیدروژل به نام ماتریژل به‌کار برده شد. ماتریژل یک زیست مادۀ حساس به حرارت است که در دمای بالای 20 درجۀ سانتی‌گراد تشکیل هیدروژل و نانوفیبر می‌دهد. ماتریژل حاوی لامینین، نیدوژن و برخی از فاکتورهای رشد است ...

[ 11 ] - Nanocurcumine Ameliorates Lipopolysaccharide-induced Depressive-like Behavior in Mice

Objective(s): Curcumin, a plant alkaloid from Curcuma longa, possess antioxidant and anti-inflammatory properties. Recently, the antidepressant activities of curcumin were reported. Nevertheless, bioavailability of curcumin limits its therapeutic utility. Nanotechnology is a developing field that potentially enhances bioavailability and the plasma concentration of curcumin. This study investiga...

[ 12 ] - مقایسه فعالیت ضدمیکروبی نانوذرات ژلاتین و ژلاتین ماهی تون زردباله (Thunnus albacares) و تعیین حداقل غلظت بازدارندگی (MIC) و حداقل غلظت کشندگی (MBC)

باتوجه به بیماری های حاضر وافزایشآنتی بیوتیک ها،به طورچشمگیریمقاومتپاتوژن هابهآنتی بیوتیک ها بالارفته است. نانوتکنولوژی یکی از روش های قابل استفاده می باشد. هد...

[ 13 ] - On the Benefit of Nanocurcumin on Aluminium Phosphide-induced Cardiotoxicity in a Rat Model

Objectives: Cardiotoxicity is considered the primary cause of death in aluminum phosphide (ALP)-poisoned cases. Curcumin, the active ingredient of turmeric, is a potent protective polyphenol compound against cardiac diseases including cardiotoxicity. This study aimed to examine the probable cardioprotection potential of nanocurcumin in a rat model of ALP-induced cardiotoxicity. Methods: T...

[ 14 ] - Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies

Objective(s): Folate-targeted liposomes have been well considered in folate receptor (FR) overexpressing cells including MCF-7 and 4T1 cells in vitro and in vivo. The objective of this study is to design an optimum folate targeted liposomal formulations which show the best liposome cell uptake to tumor cells.Material and Methods: In this study, we prepared and characterized different targ...

[ 15 ] - بررسی ساختار اندام های رویشی و تکوین اندام های زایشی گیاه زیره ایرانی Boiss)B.fedtsch) Bunium persicum

زیره ایرانی Bunium persicum (Boiss.) B.Fedtsch از گیاهان خانواده Apiaceae است . میوه های آن از اقلام مهم صادراتی است و در صنایع غذایی و دارویی مورد استفاده قرار می گیرد. نظر به جایگاه و اهمیت این گیاه بومی و لزوم آشنایی با ساختارهای تشریحی و تکوینی آن، در پژوهش حاضر، نمونه هایی از گیاه جمع آوری شد. بخشهای رویشی و زایشی آن درمراحلی از تکوین با استفاده از روشهای سلول _ بافت شناسی شامل ، تثبیت نمو...

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