The development of agents for selective modulation of protein– protein interactions (PPIs) constitutes a prominent goal in drug discovery and chemical biology. Since PPIs are often mediated by well defined secondary structural elements, a promising strategy in this area has involved the stabilization or mimicry of these motifs via compact molecular scaffolds. Reflecting their abundance in prote...

Crystalline structures of geometry corresponding to trihexagonal tiling are often referred to as Kagome lattices. Natural examples of Kagome lattices are rare, but have recently been found in surface supported organics. Their particular geometry of interlacing triangles, exhibiting an ordered arrangement of hexagonal and triangular pores of different size, makes Kagome lattice structures except...

We have previously shown that the expression of periostin is significantly downregulated in human bladder cancer tissues and that periostin suppresses cell invasiveness and metastasis of cancer cells. To clarify the molecular mechanism of this suppression by periostin, we searched for periostin-binding proteins and identified TAB1, which interacts with and activates TAK1, by mass analysis of pr...

Phosphorothioate has proven to be a useful skeleton in organic synthesis as a valuable building block, in pharmaceuticals and pesticides due to its biological and physical properties. In particular, S-aryl phosphorothioate represents an important structural element in antiproliferative agents (A), pesticides (B), antibacterials (C), curing accelerators (D), antistatic agents (E), and anticholin...

Simulating solid propellant rocket motors requires solving an extremely complex, fully coupled multidisciplinary physics problem that spans a wide range of length and time scales. We have taken a staged approach in developing an integrated whole-system rocket simulation package, beginning with relatively simple physical models, geometries, and coupling in our first-generation code (GEN1), and p...