The present study was designed to determine the effects of NIK-333, a synthetic acyclic retinoid, on N-diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male F344 rats. Animals were given DEN dissolved in drinking water at a concentration of 40 p.p.m. for 5 weeks and then provided with drinking water free of DEN for 15 weeks to induce hepatocellular neoplasms. NIK-333 was administered or...

1Department of Radiology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Linkou Medical Center, Taoyuan 333, Taiwan. 2Department of Surgery, Xiamen Chang Gung Hospital, Xiamen 361000, Fujian, China. 3Department of Surgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Linkou Medical Center, Taoyuan 333, Taiwan. 4Department of Nuring, Ch...

The Sp185/333 system of genes, messages and proteins are expressed in the coelomocytes of the purple sea urchin, Strongylocentrotus purpuratus, and is an extraordinary example of diversification of a putative innate immune response system in an invertebrate. Reviewed here, is the current understanding of this complex system as illustrated by sequence comparisons of the genes, messages and deduc...

Is ionizing radiation a risk factor to diffuse panbronchiolitis? C.-M. Lin, C.-W. Wang and Y.-C. Liu From the Division of Internal Medicine, Chang Gung Memorial Hospital, 199 Tun-Hwa North Road, Taipei 105, Taiwan, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan, Healthcare center, Chang Gung Memorial Hospital, 123 Dinghu Road, Taoyuan 333, Taiw...

The prognosis is generally poor for patients who experience a cardiac arrest. Abstract The most common causes of sudden cardiac arrest are massive pulmonary embolism (PE) and acute myocardial infarction (MI). While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has been regarded as a relative contraindication for thrombolysis becaus...

Co-amoxiclav is widely used in France to treat different infectious diseases, in particular community-acquired otitis, sinusitis and pneumonia, and occasionally urinary tract infections (UTIs). While the mechanisms of resistance to co-amoxiclav have been well defined, particularly in Escherchia coli, the influence of co-amoxiclav treatment on the in vivo selection of E. coli resistant to co-amo...

Table 1. Implant Products currently available in Australia. Abstract. The paper lists 15 different commercial products containing hormonal growth promotants (HGPs). HGPs contain synthetic forms of the steroids oestrogens, androgens or progestins. Results from the USA confirm that there are small but variable reductions in marbling associated with HGP treatment of grainfinished cattle. Experimen...

Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type I (HTLV-I) and remains incurable. NIK-333, a novel synthetic retinoid, prevents the recurrence of human hepatoma after surgical resection of primary tumors. We explored the effects of NIK-333 on HTLV-I-infected T-cell lines and ATL cells. NIK-333 inhibited cell proliferation, induced G1 arrest, and resulted in massive apo...

OBJECTIVES The aim was to study whether a workplace-registered frequent short-term sick leave spell pattern was an early indicator of future disability pension or future long-term sick leave among municipal eldercare workers. SETTING The municipal healthcare sector in the city of Aarhus, which is the second largest city in Denmark. PARTICIPANTS All elder care employees who worked the entire...