A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization. In addition to an adenosine and a guanosine mimic, analogues of the noncanonical xanthosine, isoguanosine, and 2-aminoadenosine were also synthesized and found to be emissive. Isothiazolo 2-aminoadenosine, an...

The nature of the association of adenosine deaminase deficiency and severe combined immunodeficiency disease is reviewed . The basis for the molecular heterogeneity exhibited by adenosine deaminase in human tissue and the mechanisms whereby a deficiency of this activity results in the extreme perturbation of the immune system as observed in severe combined immunodeficiency are critically discus...

Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems. Previous experiments have shown that through the action of specific kinases, nucleosides can be "trapped"...

This study was aimed to determine normal serum adenosine deaminase (ADA) activity in domestic animals in both sexes and that were considered healthy on the basis of clinical and laboratory examinations. In this study, 262 non-pregnant animals of both sexes, belonging to 5 species [cattle (n = 50), sheep (n = 65), goat (n = 52), dog (n = 55), and cat (n = 40)] were used. Serum total ADA and ADA1...

Cultured leukemic T-lymphoblasts, incubated in the pres ence of inhibitors of adenosine deaminase, are exquisitely sensitive to growth inhibition by deoxyadenosine. An analogy between this phenomenon and human combined immunodefi ciency disease associated with inborn adenosine deaminase deficiency and the use of inhibitors of adenosine deaminase in the management of T-cell acute lymphoblastic l...

Chronic obstructive pulmonary disease (COPD) has been defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), as a disease state characterized by airflow limitation which is not fully reversible. COPD consists of emphysema which is the destruction and inflammation of the lung alveoli. Adenosine deaminase (ADA, E.C.3.5.4.4) converts adenosine to inosine. There are two isoen...

ceeds supply.@ Adenosine measurement is difficult in any given circumstance, as elements such as endothe hal cell and blood uptake and release, interstitial concentration, intracellular binding with SAH-hydro lase, and flow all influence venous adenosine concen trations. Adenosine is removed from tissues either by phos phorylation to AMP by adenosine kinase or by deam ination by adenosine deami...

OBJECTIVE Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about hemorrhagic fever viruses, little is known about the pathogenesis of Crimean-Congo hemorrhagic fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in Crimean-Congo hemorrhagic fever patients. METHODS Serum adenosine de...

The current work aimed to study the effect of preeclampsia on maternal serum level of beta subunit of human chorionic gonadotropin and maternal plasma level of adenosine deaminase. Ninety pregnant women with gestational age 24 26 weeks were selected for this study, they were classified into three groups: group 1 consists of 30 women with normal pregnancy, group 2 consists of 30 patients with mi...

Alcohol consumption is associated with a number of changes in hepatic cell functions as liver is the major site of its metabolism. Acetaldehyde metabolite formed during metabolism of ethanol is very reactive compound and is indicator of tissue and organ damage. The relationship of serum sialic acid, adenosine deaminase and C-reactive protein in patients of alcohol abuse is unknown so the curren...