chronic obstructive pulmonary disease (copd) has been defined by the global initiative for chronic obstructive lung disease (gold), as a disease state characterized by airflow limitation which is not fully reversible. copd consists of emphysema which is the destruction and inflammation of the lung alveoli. adenosine deaminase (ada, e.c.3.5.4.4) converts adenosine to inosine. there are two isoen...

Background: In recent years, numerous regulators of gonadal function have been studied. Adenosine deaminase(ADA) is widely distributed throughout human tissues and may contribute in the regulation of menstrual cycle. The purpose of this study was to determine the plasma activities of total adenosine deaminase (ADAT), and its isoenzymes, ADA1 and ADA2, and ADA1/ADA2 ratio during the menses, foll...

The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleosides: adenosine and 2'deoxyadenosine, producing inosine and 2'deoxyinosine. Adenosine and 2'deoxyadenosine are molecules with many effects on human cells [1–4]. Thus, the homeostasis of these substances and the activity of the isoenzymes ADA1 and ADA2 in human cells are of extreme importance.

Background Some studies have revealed enzymatic and non-enzymatic roles of adenosine deaminase (ADA) in male reproductive system such as regulating adenylate cyclase activity by decreasing adenosine concentration, helping to interaction between prostasomes and spermatozoa. MaterialsAndMethods frequency distribution of ADA1 G22A alleles and genotypes in 200 fertile and 200 infertile men. The pol...

Human adenosine deaminase (ADA; EC 3.5.4.4) consists of three isoenzymes: ADA1, ADA1+CP, and ADA2. We developed an electrophoretic technique to distinguish between these three isoenzymes. The isoenzyme pattern was studied in tissue and cell homogenates, as well as in serum from normal subjects and from patients with increased serum ADA who had either hepatitis, infectious mononucleosis, tubercu...

We read with great interest the editorial by GAKIS [1] about the extreme importance of the adenosine deaminase (ADA) isoenzymes ADA1 and ADA2 on the homeostasis of 2' deoxyadenosine and adenosine, especially when monocytes and macrophages are infected by intracellular microorganisms. Serum ADA activity is increased in various conditions such as liver disease, tuberculosis, typhoid, infective mo...

background and objective: brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in iran. adenosine deaminase (ada) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. the aim of this study was to determine serum changes of ada and c-reactive protein (crp) levels in patients with brucellosis. ...