b a ckground: diabetes is an important disease. this disease is a metabolic disorder characterized by hyperglycemia resulting from perturbation in insulin secretion, insulin action or both. honey bee venom contains a wide range of polypeptide agents. the principle components of bee venom are mellitin and phospholipase a2. these components increase insulin secretion from the β-cells of pancreas....

Hypoglycemic and hypolipidemic effects of Aerva lanata (Linn.) on alloxan induced diabetic ratsRamalingam Vidhya , Rajangam Udayakumar

Hypoglycemic activity of methanolic extract Tectona grandis linn. Root in alloxan induced diabetic ratsPooja,Vipin Sharma, K.C.Samanta

Butterfly pea flower (Clitoria Ternatea L.) contains flavonoids, tannins, and triterpenoids, which contain flavonoid compounds that have the potential as antioxidants. Antioxidants can suppress beta cell apoptosis without changing proliferation of pancreatic cells. bind free radicals so they reduce insulin resistance. The novelty this study was it examined effectiveness ethanol extract from but...

In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses...

1. Microsomal prostaglandin synthesis and tissue prostaglandin concentrations in the kidneys of rats made diabetic by pretreatment with alloxan or streptozotocin were significantly decreased but were unchanged in lungs. 2. Prostaglandin inactivation was increased in kidneys of alloxan-diabetic rats but not changed in streptozotocin-diabetic kidneys or in the lungs of either group. 3. These chan...

Rats can be made diabetic by pancreatectomy (Scow, 1957) or by the administration of alloxan (Lukens, 1948) or of anti-insulin serum (Armin, Grant & Wright, 1960b). Some of the metabolic abnormalities in pancreatectomized (Scow & Chernick, 1960) and alloxan-diabetic (Lukens, 1948; Spiro & Hastings, 1958) rats have been studied, but little is known about the serum-treated animals. The observatio...

Anoxia and KC1 have been used to inactivate peripheral nerves by depolarization conduction block. Investigation of the inactivation patterns in isolated sciatic nerves of healthy and alloxan-diabetic rats suggests that the paranodal gap substance of healthy nerve behaves as an effective periaxonal diffusion barrier. In diabetic nerve the permeability of this barrier is significantly increased. ...

The activities of two enzymes viz: Na(+)-K(+)-ATPase and succinic dehydrogenase (SDH) in brain and liver of alloxan diabetic Swiss albino mice are reported. Alloxan diabetes caused significant decrease in the activity of Na(+)-K(+)-ATPase reflecting reduced glucose transport across the cell membrane. On the contrary, the observed enhanced activity of the enzyme SDH is attributed to increased su...

The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high incidence of diabetes mellitus (DM) in the rat experiment model. Rats were randomly divided into STZ, Alloxan and control groups. 1-Alloxan group was divided into two subgroups: intraperitoneal (i...