Introduction As a rule dead neurons in the adult central nervous system (CNS) are not replaced nor can their terminals regenerate when their axons are interrupted. Therefore any pathological process causing neuronal death generally has irreversible consequences. Alzheimer disease (AD) is a disabling senile dementia, the loss of reasoning and ability to care for oneself that afflicts about 11% o...

Alzheimer’s disease is a brain disturbance characterized by a progressive dementia. It is the very costly disease in the today’s society & characterized by cognitive decline, cerebral as well as behavioral action disturbance. Because of this, the early stage of the Alzheimer’s disease is detected, as it assists the patients & also his relative to take precautionary measures. As electroencephalo...

Alzheimer disease (AD), the most common cause of dementia, is an irreversible progressive neurodegenerative condition. It is characterized by the salient inflammatory features, microglial activation and increased levels of pro-inflammatory cytokines which contribute to the inflammatory states of the CNS. Accumulating data suggest the key role of inflammation in AD pathogenesis. In a prospective...

Alzheimer’s disease is a brain disturbance characterized by a progressive dementia. It is the very costly disease in the today’s society & characterized by cognitive decline, cerebral as well as behavioral action disturbance. Because of this, the early stage of the Alzheimer’s disease is detected, as it assists the patients & also his relative to take precautionary measures. As electroencephalo...

Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease-like pathologies. This model demonstrates an altered immune redox state rem...

OBJECTIVE To determine whether patients with Alzheimer disease (AD) compensate for neuropathologic changes when performing a mnemonic task by recruiting 1) the same brain regions as age-matched, healthy controls, but to a greater extent; 2) additional brain regions not activated by controls; or 3) both. METHODS Twelve patients with mild probable AD and 12 healthy age- and education-matched co...

abstract alzheimer’s disease (ad) is the most common form of dementia has become one of the most severe progressive socio-economical and medical burdens facing countries all over the world. the drugs are currently available just able to delay the symptom progression of disease. this study try to evaluate protein profile of the effects of aqueous extract of lavender ( lavandula angustifolia ) on...

OBJECTIVE To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD). METHODS We compared t-tau and p-tau and 18F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (pro...

Background and Objective: Alzheimer’s disease (AD) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. With regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of Alzheim...