the two stable isotopes of hydrogen, protium (1h) and deuterium (2h) differ in their physicochemical nature. deuterium-depleted water (ddw) significantly inhibited the growth rate of different tumor cell lines in culture media and xenotransplanted mda-mb-231, mcf-7 human breast adenocarcinomas and pc-3 human prostate tumors in vivo. the apoptosis-triggering effect of ddw was demonstrated both i...

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

Objective- The studies have been shown that aspirin, an anti-inflammatory agent, could reduce occurrence of different cancers. The aim of the present study was to evaluate pharmacological effective concentrations of aspirin with/without radiotherapy on growth rate of MCF-7 breast cancer cell line Design- Experimental Study Animals- The MCF-7 breast cancer cell line from rats P...

paraneoplastic cerebellar degeneration is a rare, fatal neuronal syndrome associated with ovarian, breast and lung cancers. anti-yo antibody mediated paraneoplastic cerebellar degeneration is known to be associated with gynecological malignancies, especially ovarian cancer. however, there are no reports of anti-yo antibody associated predominant peripheral mixed sensory and motor neuropathy in ...

Breast cancer is a major public health problem worldwide in women and existing treatments are not adequately effective for this deadly disease. microRNAs (miRNAs) regulate the expression of many target genes and play pivotal roles in the development, as well as in the suppression of many cancers including breast cancer. We previously observed that miR-203 was highly upregulated in breast cancer...

The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in treatment restoration normalcy patients. However, most therapeutic strategies employed are challenged high cost, efficacy, toxicity, multiple side effects. In recent times, emergent studies provided evidence that functional foods their b...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

Background: Mucin1 (MUC1) is a highly glycosylated transmembrane protein that has gained attention because of its overexpression in various cancers. However, MUC1-targeted therapeutic antibodies have not yet been approved for cancer therapy. MUC1 is cleaved to two subunits, MUC1-N and MCU1-C. MUC1-N is released from the cell surface, making MUC1-C a more reasonable target for cancer therapy. Th...

Human umbilical cord mesenchymal stem cells (hUCMSCs) derived from the umbilical cord matrix have been reported to be used as anti-tumor gene carrier for attenuation of tumor growth, which extends the half-life and lowers the unexpected cytotoxicity of the gene in vivo. Interferon-β (IFNβ) is known to possess robust anti-tumor effects on different types of cancer cell lines in vitro. The presen...