Candida haemulonii, one of the non-albicans Candida species, is an emerging yeast pathogen that is known to be resistant to amphotericin B and other antifungal agents such as azoles. These anti-fungal agents have often been associated with clinical treatment failure, so no treatment regimen has been clearly established for invasive C. haemulonii infections. We investigated a catheter-related in...

Professor of Biology University of Texas at San Antonio Candidiasis Drug Discovery and Development: New Approaches Targeting Virulence for Discovering and Identifying New Antifungal Drugs Targeting pathogenetic mechanisms rather than essential processes represents a very attractive alternative for the development of new antibiotics. This may be particularly important in the case of antimycotics...

Cinnamon is the bark the cinnamomi cassia that exhibits many medical properties such as anti-cancer effect and anti-diabetic effect. Moreover, because of its antioxidant activity; it can be used in food industries. Many studies have already reported biological and chemical properties of the cinnamon extracted essential oil such as their antimicrobial, antifungal, antimosquito, free radical scav...

Background Understanding perception of risks and benefits is essential for informed patient choices regarding medical care. The primary aim of this study was to evaluate the perception of risks and benefits of 9 drug classes during pregnancy and associations with women's characteristics. Methods Questionnaires were distributed to pregnant women who attended a Dutch Obstetric Care facility (fi...

Oregano (Origanum vulgare L.) is one of the most selled culinary and medicinal herb throughout the world. Flowering aerial parts and leaves of oregano have been used as a popular flavoring of food stuffs and as an antioxidant agent in cosmetics. Oregano contains a wide array of active components, including flavonoids, phenolic acids and glucosides, phenols and triterpenes. Several biological ac...

C. odorata L. is considered to be a plant weed that scattered in various climates. As weed, this contains variety of beneficial secondary metabolites. Several studies have shown the benefits leaf extract. This study reviews metabolite content and pharmacological activities A literature search was carried out obtain related use Secondary metabolites identified are alkaloids, flavonoids, tannins,...

Ascosphaera apis is a bee pathogen that causes bee larvae infection disease, to which treatment is not yet well investigated. The aim of this study was to investigate antifungal susceptibility in vitro against A. apis and to identify a new antifungal agent for this pathogen through minimal inhibitory concentration (MIC) assay and western blot analysis. Macelignan had 1.56 and 3.125 μg/mL MIC ag...

Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistant Candida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a sma...