نتایج جستجو برای: balanced lna
تعداد نتایج: 48042 فیلتر نتایج به سال:
Low biological activity and inefficient targeted delivery in vivo have hindered RNA interference (RNAi)-based therapy from realising its full clinical potential. To overcome these hurdles, progresses have been made to develop new technologies optimizing oligonucleotides chemistry on one hand and achieving its effective delivery on the other hand. In this report, we achieved, by using the electr...
BACKGROUND MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular diseases such as cardioprotection of murine hearts after myocardial infarction via miR-92a inhibitors. Because the functional benefits of miR-92a inhibitors in larger preclinical models are not kno...
مخابرات رادیویی فراپهن باند (uwb) یک تکنولوژی برای انتقال و دریافت اطلاعات کد شده و ضربه¬های الکترومغناطیسی است که از مزایای آن می¬توان به انتقال سیگنال دیجیتال با نرخ بالای داده همراه با مصرف توان بسیار کم، پیچیدگی کم¬ و امنیت بالا اشاره کرد. به دلیل پیشرفت سریع مخابرات بی¬سیم، پیاده¬سازی سیستم¬های درون-تراشه¬ای (soc)، نیازمند عملکرد خوب، تکنولوژی مجتمع¬سازی بالا و هزینه کم می¬باشد. در این میا...
A b s t r a c t Keywords: Cascode Topology Low Noise Amplifier Noise Figure Particle Swarm Optimization Design of a LNA is a complex process. Because it involves various parameters and needs complex trade-offs. This paper presents an optimized design of a low noise amplifier (LNA) using particle swarm optimization (PSO) technique. The proposed LNA has a cascode structure with inductive source d...
A CMOS low-noise amplifier (LNA) and mixer for a GPS front end is described. At 1.586Ghz the LNA minimum noise figure (NF) is 2.8dB, input third order intercept point (IIP3) is 2.45dB and forward gain is 30dB. With a 1.573Ghz local oscillator (LO) and a 1.586Ghz RF input the mixer minimum NF is 6.1dB, IIP3 is 12dB and a conversion gain of -3dB. The LNA and mixer consume 58mW of power from a 1.8...
This paper proposes a wideband common-gate LNA using capacitive feedback. The transconductance of the proposed LNA can be enlarged and noise figure can be improved while the conventional common-gate LNA has to use a smaller transconductance for the input impedance matching. In the experimental results using a 0.18-μm CMOS technology, the gain is 13.4 dB, NF is 2.7 dB, IIP3 is −7 dBm at 0.8GHz, ...
MicroRNAs are dysregulated in a setting of heart disease and have emerged as promising therapeutic targets. MicroRNA-34 family members (miR-34a, -34b, and -34c) are up-regulated in the heart in response to stress. In this study, we assessed whether inhibition of the miR-34 family using an s.c.-delivered seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiR (LNA-antimiR-34) can provide...
Two unusual reactions involving the 5-hexenyl or the 6-heptenyl radical cyclization of a distant double bond at C4' and the radical center at C2' of the ribofuranose ring of thymidine have been used as key steps to synthesize North-type conformationally constrained cis-fused bicyclic five-membered and six-membered carbocyclic analogues of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) in h...
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked nucleic acids (LNA), have sometimes been stifled by safety liabilities related to their accumulation in the kidney tubule. In an attempt to predict...
The LNA is implemented using 90nm CMOS technology. The cascode topology with single-ended source degeneration using inductor is employed. The high gain is achieved by using common-source (CS) amplifier. A different input matching as well as output matching topology may improve the efficiency and minimize noise of the LNA. An inductance network (Lg, Ls) is used for input matching. An interstage ...
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