Alzheimer’s disease (AD) is the most common form of progressively disabling degenerative dementia. In dementia in general, there are, unfortunately, even from earliest stages disease, associated behavioural and psychological symptoms (BPSD), more pronouncedly AD, addition to cognitive impairment. There are no specific drugs for treatment BPSDs. Therefore, remains an unmet medical need. To date,...

Background To investigate the effects of benzodiazepine receptor agonists on cognitive function in patients with chronic insomnia. Method According to history taking hypnotic drugs, they were divided into no medication group (n = 62), benzodiazepines 57) and non-benzodiazepines 53); all subjects The Pittsburgh Sleep Quality Scale, Epworth Insomnia Severity Index used evaluate their sleep qualit...

Nonhuman and human studies comparing the abuse liability of alprazolam to other commonly used benzodiazepines are reviewed. These studies are reviewed to determine to what extent prospective, controlled, experimental studies support opinions that alprazolam's abuse liability is greater than that of other commonly used benzodiazepines. Studies comparing the self-administration of alprazolam, the...

was positive but the rest of tested benzodiazepines were negative. Previous reports2 suggest that there is no cross-reactivity among benzodiazepines. Diazepam is the most similar benzodiazepine to tetrazepam, the only difference between them is the presence at position 5 on the diazepine ring of phenyl in diazepam and clohexen in tetrazepam, and this cyclohexene conformation could explain tetra...