ôbjective: the purpose of the present preliminary study was to explore the prevalence of nonmedical abuse of benzodiazepines in a group of opiate-dependent patients who were on methadone maintenance treatment (mmt) program in outpatient clinics in the south-west of tehran, ïran. methods: 114 male and female opiate-dependent clients who met dsm.ïv-tr criteria for opiate dependence with mean age ...

Phlegmatic people dislike taking benzodiazepine drugs. In those with low'anxiety traits benzodiazepines are dysphoric and may paradoxically increase anxiety.' In normal subjects benzodiazepines improve performance under experimental stress but worsen it under conditions of low stress.2 Benzodiazepines relieve preoperative anxiety in patients with high anticipatory anxiety but not in those with ...

BACKGROUND The use of benzodiazepine anxiolytics and hypnotics continues to excite controversy. Views differ from expert to expert and from country to country as to the extent of the problem, or even whether long-term benzodiazepine use actually constitutes a problem. Although as a class benzodiazepines act rapidly and are well tolerated, their use presents clinical issues such as dependence, r...

Benzodiazepines possess a wide spectrum of valuable pharmacological effects and are among the leading drugs, commonly prescribed ones for various pathologies. Herein we describe continuous flow synthesis six benzodiazepines from aminobenzophenones: diazepam, fludiazepam, nordazepam, nitrazepam, clonazepam, oxazepam.

In a recent publication, the authors reported a liquid chromatography-mass spectrometry-time of flight procedure for the simultaneous analysis of 22 benzodiazepines in urine specimens. In this report, the list of benzodiazepines that could be analyzed was expanded to 35 benzodiazepines, and data for the additional 13 analytes are presented. The analysis focused on the most commonly prescribed b...