A beta-lactamase prevalence of 23% was found among 1,730 Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of beta-lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxaci...

background: acinetobacter baumannii is gram- negative opportunistic coccobacilli, the most important agent in nosocomial infections with high mortality rate. multidrug resistance in strains isolated from nosocomial infections , making it difficult to treat and sometimes impossible. the aim of the present study was to investigate antibiotic resistance in a. baumannii isolates from iranian patien...

results amc-susceptible esbl-producing escherichia coli, klebsiella pneumoniae and k. oxytoca were identified as the causative agents in 31, 14, and 1 patients, respectively. thirty-nine (84.7%) out of 46 patients were successfully treated with oral amc. additionally, 2 (4.3%) patients’ urine cultures turned to be negative, though their clinical complaints and leukocyturia had continued. in the...

conclusions: our findings suggest the possible co-carriage of some blashv genes and aris on the same plasmids harboring the mdr genes. possible role of integrons in dissemination of esbl-encoding blashv genes among esbl-producing k. pneumoniae nosocomial isolates may be inferred. background: some genetic and phenotypic variables are associated among distinct microbial populations. objectives: t...

Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance. In the past, extensive research has focused on the structure, function, and ecology of beta-lactamases while limited efforts were placed on the regulatory mechanisms of beta-lactamases. Recently, increasing evidence demonstrate a direct link...

beta-Lactamases represent the major resistance mechanism of gram-negative bacteria against beta-lactam antibiotics. The amino acid sequences of these proteins vary widely, but all are located in the periplasm of bacteria. In this study, we investigated the translocation mechanism of representative beta-lactamases in an Escherichia coli model. N-terminal signal sequence analyses, antibiotic acti...

The influence of growth medium and incubation conditions on the detection of Bilophila wadsworthia beta-lactamase was tested with Cefinase and Cefinase Plus disks. The tests involved aerobic and anaerobic incubation with conventional disk and quantitative tube assays. The production of beta-lactamase was correlated with penicillin G, ampicillin, and ampicillin-sulbactam MICs and inhibition zone...

results the most effective agent against the studied isolates was colistin. by cddt, it was found that among 278 imipenem resistant p. aeruginosa strains, 178(64.02%) were mbl producers. the blaimp-1 and blavim-1 genes were detected in 30(16.8%) and 52(29.2%) of p. aeruginosa isolates, respectively. result of 187 imipenem resistance a. baumannii strains showed that 85(45.4%) were mbl producers....

conclusions the inter- and intra-hospital dissemination of resistant clones is a matter of concern and is an indicator of the level of the improvement and surveillance of standard hygiene, particularly disinfection and hand washing before and after contact with patients. given the emergence of mbl-producing strains, surveillance has become an important procedure to control the transmission of r...