Alterations in the human 13q14 genomic region containing microRNAs mir-15a and mir-16-1 are present in most human chronic lymphocytic leukemia (CLL). We have previously found the development of CLL in the New Zealand Black murine model to be associated with a point mutation in the primary mir-15a/16-1 region, which correlated with a decrease in mature miR-16 and miR-15a levels. In this study, a...

We present line and continuum measurements for 9818 SDSS type-I active galactic nuclei (AGNs) with z ≤ 0.75. The data are used to study the four dimensional space of black hole mass, normalized accretion rate (L/LEdd), metalicity and redshift. The main results are: 1. L/LEdd is smaller for larger mass black holes at all redshifts. 2. For a given black hole mass, L/LEdd∝ zγ or (1 + z)δ where the...

The central black-hole masses of a sample of 30 luminous quasars are estimated using Hβ fwhm measurements from a combination of new and previously-published nuclear spectra. The quasar black-hole mass estimates are combined with reverberationmapping measurements for a sample of Seyfert galaxies (Wandel, Peterson & Malkan 1999) in order to study AGN black-hole masses over a wide range in nuclear...

Microphthalmia-associated transcription factor (Mitf) is a key regulator for differentiation of melanoblasts, precursors to melanocytes. The mouse homozygous for the black-eyed white (Mitfmi-bw) allele is characterized by the white-coat color and deafness with black eyes due to the lack of melanocytes. The Mitfmi-bw allele carries LINE-1, a retrotransposable element, which results in the Mitf d...

In this paper we present a fully relativistic approach to modelling both the continuum emission and the reflected fluorescent iron line from a primary X-ray source near a Kerr black hole. The X-ray source is located above an accretion disc orbiting around the black hole. The source is assumed to be a static point source located on an arbitrary position above the disc, on or off the axis of rota...

The observed iron Kα fluorescence lines in Seyfert I galaxies provide strong evidence for an accretion disk near a supermassive black hole as a source of the line emission. These lines serve as powerful probes for examining the structure of inner regions of accretion disks. Previous studies of line emission have considered geometrically thin disks only, where the gas moves along geodesics in th...

Controversy regarding whether Narrow Line Seyfert 1 galaxies (NLS1s) follow the same black hole — galactic bulge relation as normal galaxies has been raised by Mathur et al. (2001) and Ferrarese et al. (2001). In this paper, the correlation between the black hole mass and the velocity dispersion of the narrow line region, indicated by the [OIII] line width for a heterogeneous sample of NLS1s, i...

Aims. Type II AGNs with polarimetric broad emission line provided strong evidence for the orientation-based unified model for AGNs. We want to investigate whether the polarimetric broad emission line in type II AGNs can be used to calculate their central supermassive black hole (SMBH) masses, like that for type I AGNs. Methods. We collected 12 type II AGNs with polarimetric broad emission line ...